Comfortis hund

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Trifexis ® (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet that kills fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm*, roundworm and whipworm infections. It’s an easy and effective way to get a little peace of mind, even if you don’t own 3 dogs.

Trifexis is approved for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.

IMPORTANT SAFETY INFORMATION

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

The most common adverse reactions reported are vomiting, depression/lethargy, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Like all medications, keep Trifexis out of reach of children.

ELANCO

PACK 2 X COMFORTIS 425 MG FÜR HUNDE UND KATZEN 6 KAUTABLETTEN

Behandlung und Vorbeugung von Befall mit Flöhen

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Comfortis 425 mg Kautabletten für Hunde und Katzen

Die vorbeugende Wirkung gegen einen erneuten Befall mit Flöhen ist eine Folge der adultiziden

Wirkung und der Reduktion der Eiproduktion und hält für bis zu 4 Wochen nach einer einmaligen

Anwendung des Tierarzneimittels an.

Das Tierarzneimittel kann als Teil der Behandlungsstrategie zur Kontrolle der allergischen

Flohdermatitis (FAD) verwendet werden.

Comfortis 140 mg Spinosad 140 mg

Comfortis 180 mg Spinosad 180 mg

Comfortis 270 mg Spinosad 270 mg

Comfortis 425 mg Spinosad 425 mg

Comfortis 665 mg Spinosad 665 mg

Comfortis 1040 mg Spinosad 1040 mg

Comfortis 1620 mg Spinosad 1620 mg

Nicht anwenden bei Hunden und Katzen im Alter von unter 14 Wochen.

Nicht anwenden bei bekannter Überempfindlichkeit gegenüber dem Wirkstoff oder einem der

Das Tierarzneimittel sollte mit dem Futter oder unmittelbar nach der Fütterung verabreicht werden.

Die Wirksamkeitsdauer kann verkürzt sein, wenn die Dosis auf leeren Magen verabreicht wird.

Es sollten alle zum Haushalt gehörenden Hunde und Katzen behandelt werden.

Von Haustieren stammende Flöhe befallen oft das Körbchen, den Schlafplatz und regelmäßig benutzte

Ruhebereiche wie z. B. Teppiche oder Sessel. Diese sollten bei massivem Befall und zu

Behandlungsbeginn mit einem geeigneten Insektizid behandelt und regelmäßig gesaugt werden.

Flöhe können für eine gewisse Zeit nach Anwendung des Tierarzneimittels vorhanden sein, da sich

adulte Flöhe aus den bereits in der Umgebung befindlichen Puppen entwickeln. Die regelmäßige

monatliche Anwendung von Comfortis unterbricht den Lebenszyklus der Flöhe und kann daher für die

Kontrolle der Flohpopulation in kontaminierten Haushalten erforderlich sein.

Besondere Vorsichtsmaßnahmen für die Anwendung bei Tieren

Bei Hunden und Katzen mit bekannter Epilepsie mit Vorsicht anwenden.

Bei Hunden mit einem Gewicht von unter 1,3 kg und bei Katzen mit einem Gewicht von unter 1,2 kg

ist eine genaue Dosierung nicht möglich, daher wird die Anwendung des Tierarzneimittels bei

kleineren Hunden und Katzen nicht empfohlen.

Die empfohlenen Dosierungen sind zu beachten (siehe Abschnitt 4.10 bezüglich Informationen zu

Die versehentliche Einnahme kann unerwünschte Reaktionen verursachen.

Kinder sollten keinen Zugriff auf dieses Tierarzneimittel haben.

Bei versehentlicher Einnahme ist unverzüglich ein Arzt zu Rate zu ziehen und die Packungsbeilage

oder das Etikett vorzuzeigen.

der Verabreichung auftritt und höchstwahrscheinlich von einer lokalen Wirkung auf den Dünndarm

verursacht wird. In der Feldstudie trat Erbrechen am Tag oder am Tag nach der Verabreichung von

Spinosad in einer Dosierung von 45 – 70 mg/kg Körpergewicht in einer Häufigkeit von 5,6%, 4,2%

und 3,6% jeweils nach der ersten, zweiten bzw. dritten monatlichen Behandlung auf. Bei Hunden, die

eine Dosis im oberen Dosisbereich erhielten, war die Inzidenz nach der ersten und zweiten

Behandlung höher (8%). In der Mehrzahl der Fälle war das Erbrechen vorübergehend, mild und

erforderte keine symptomatische Behandlung.

Andere, gelegentliche oder seltene unerwünschte Nebenwirkungen bei Hunden waren Lethargie,

Anorexie, Diarrhoe, Ataxie oder Krampfanfälle.

Bei Katzen ist Erbrechen eine häufig beobachtete Nebenwirkung, die in den ersten 48 Stunden nach

der Verabreichung auftritt und höchstwahrscheinlich durch eine lokale Wirkung auf den Dünndarm

verursacht wird. In der globalen Feldstudie trat Erbrechen am Tag der Verabreichung von Spinosad in

einer Dosierung von 50-75 mg/kg Körpergewicht bzw. einen Tag später in den ersten drei

Behandlungsmonaten in einer Häufigkeit von 6 bis 11 % auf. In der Mehrzahl der Fälle war das

Erbrechen vorübergehend, mild und erforderte keine symptomatische Behandlung.

Andere häufig beobachtete Nebenwirkungen bei Katzen waren Diarrhoe und Anorexie. Lethargie,

Konditionsverlust und Speichelbildung traten gelegentlich auf. Krampfanfälle waren seltene

In Laborstudien an Ratten und Kaninchen wurden weder Anzeichen einer teratogenen, fetotoxischen

oder maternotoxischen Wirkung von Spinosad noch Wirkungen auf die Fortpflanzungsfähigkeit von

männlichen und weiblichen Tieren festgestellt.

Sicherheit von Spinosad bei trächtigen Katzen wurde nicht untersucht.

Bei Hunden wird Spinosad im Kolostrum und in der Milch von laktierenden Hündinnen

ausgeschieden; es wird daher davon ausgegangen, dass Spinosad auch im Kolostrum und in der Milch

von laktierenden Katzen ausgeschieden wird. Da die Unbedenklichkeit für säugende Hunde- und

Katzenwelpen nicht ausreichend geprüft wurde, sollte das Tierarzneimittel während der Trächtigkeit

und Laktation nur nach einer Nutzen-Risikobewertung durch den verantwortlichen Tierarzt

Spinosad ist ein Substrat des P-Glykoproteins (PgP). Spinosad könnte daher mit anderen PgPSubstraten

(zum Beispiel Digoxin, Doxorubicin) interagieren und möglicherweise unerwünschte

Nebenwirkungen solcher Moleküle verstärken oder die Wirksamkeit beeinträchtigen.

Berichte nach der Markteinführung über die gleichzeitige Anwendung von Comfortis mit ‘Off label’

hohen Dosen von Ivermectin bei Hunden weisen darauf hin, dass es bei diesen Hunden zu 5

Zittern/Zuckungen, Speichelfluss/Sabbern, Krämpfen, Ataxie, Mydriasis, Blindheit und

Das Tierarzneimittel sollte mit dem Futter oder unmittelbar nach der Fütterung verabreicht werden.

Das Tierarzneimittel sollte bei Hunden in einer Dosierung von 45 – 70 mg pro kg Körpergewicht

entsprechend der folgenden Tabelle verabreicht werden:

Körpergewicht (kg) des

Anzahl der Tabletten und Tablettenstärke

1,3 – 2,0 1x 90 mg Tablette

2,1 – 3,0 1x 140 mg Tablette

3,1 – 3,8 2x 90 mg Tabletten

3,9 - 6,0 1x 270 mg Tablette

6,1 - 9,4 1x 425 mg Tablette

9,5 - 14,7 1x 665 mg Tablette

14,8 - 23,1 1x 1040 mg Tablette

23,2 - 36,0 1x 1620 mg Tablette

36,1 - 50,7 1x 1620 mg Tablette + 1x 665 mg Tablette

50,8 - 72,0 2x 1620 mg Tabletten

Das Tierarzneimittel sollte bei Katzen in einer Dosierung von 50 – 75 mg pro kg Körpergewicht

entsprechend der folgenden Tabelle verabreicht werden:

Körpergewicht (kg) der

Anzahl der Tabletten und Tablettenstärke

1,2 - 1,8 1x 90 mg Tablette

1,9 - 2,8 1x 140 mg Tablette

2,9 - 3,6 2x 90 mg Tabletten

3,7 - 5,4 1x 270 mg Tablette

5,5 - 8,5† 1x 425 mg Tablette

Tablette nicht direkt annimmt, kann sie mit dem Futter verabreicht werden, oder direkt, indem Sie die

Schnauze des Tieres öffnen und die Tablette auf den Zungengrund legen.

Falls es innerhalb einer Stunde nach der Verabreichung zu Erbrechen kommt und die Tablette sichtbar

ist, geben Sie dem Tier eine weitere volle Dosis, um die maximale Wirksamkeit des Mittels zu

monatlichen Dosisplan erneut beginnen.

Das Tierarzneimittel kann in der empfohlenen Dosis unbedenklich in monatlichen Intervallen

verabreicht werden. Die insektiziden Eigenschaften des Tierarzneimittels halten für bis zu 4 Wochen 6

nach einer einmaligen Verabreichung an. Sollten Flöhe in der vierten Woche wieder auftreten, kann

das Behandlungsintervall bei Hunden um bis zu 3 Tage verkürzt werden. Bei Katzen sollte die

Behandlungspause von vollen 4 Wochen eingehalten werden, auch wenn Flöhe vor dem Ende der vier

Wochen erneut auftreten.

Lassen Sie sich von einem Tierarzt über den optimalen Zeitpunkt für den Beginn der Behandlung mit

diesem Tierarzneimittel beraten.

Es gibt kein Antidot. Bei unerwünschten Nebenwirkungen sollte das Tier symptomatisch behandelt

Die Häufigkeit von Erbrechen am Tag oder am Tag nach der Behandlung nimmt in Abhängigkeit der

Dosis zu. Erbrechen wird höchstwahrscheinlich von einer lokalen Wirkung auf den Dünndarm

verursacht. Bei Dosen über der empfohlenen Dosis tritt Erbrechen sehr häufig auf. In Dosierungen von

ungefähr dem 2,5-fachen der empfohlenen Dosis führte Spinosad bei der überwiegenden Mehrzahl der

Hunde zu Erbrechen.

Bei Dosen bis zu 100 mg/ kg Körpergewicht pro Tag für 10 Tage war Erbrechen das einzige klinische

Symptom der Überdosierung und trat innerhalb von 2,5 Stunden nach der Dosis auf. Bei allen mit

Comfortis behandelten Hunden kam es zu einem milden Anstieg der ALT (Alaninaminotransferase),

wobei die ALT-Werte bis Tag 24 zu ihren Ausgangswerten zurückkehrten. Ebenso wurden Anzeichen

einer Phospholipidose (Vakuolenbildung des lymphatischen Gewebes) beobachtet, die allerdings zu

keinen klinischen Symptomen bei Hunden führten, die bis zu 6 Monate behandelt wurden.

Bei Katzen verursachte Spinosad nach einer einmaligen akuten Überdosis , die der 1,6-fachen

maximal empfohlenen Dosierung entspricht, bei ungefähr der Hälfte der Tiere Erbrechen und in

seltenen Fällen Abgeschlagenheit, Umherlaufen/Hecheln und schwere Diarrhoe.

Bei Dosen von 75 bis 100 mg/kg Körpergewicht pro Tag über 5 aufeinander folgende Tage ,

verabreicht in monatlichen Intervallen über einen Zeitraum von sechs Monaten , war das am

häufigsten beobachtete klinische Symptom Erbrechen.

Bei weiblichen Katzen wurde außerdem eine verminderte Futteraufnahme, jedoch kein signifikanter

Verlust des Körpergewicht beobachtet. Phospholipidose (Vakuolisierung der Zellen in der Leber,

Nebenniere und Lunge) ist ebenfalls aufgetreten. Zudem wurde bei männlichen und weiblichen Tieren

eine diffuse hepatozelluläre Hypertrophie festgestellt; dieser Befund deckt sich auch mit höheren

mittleren Lebergewichten. Es gab jedoch keine Anzeichen aus klinischen Beobachtungen und

klinisch- chemischen Parametern, die auf einen Verlust von Organfunktionen hinwiesen.

Comfortis Flea piller til hunde: Better Than Lufenuron

I fortiden, den bedste løsning loppe pille var en, der indeholdt den aktive Lufenuron. I de senere år har en ny pille fremkom kaldet Comfortis. Denne gang en pille en måned er det væsentlige erstattet Lufenuron Du kan dog stadig købe den gamle online.

Så er den nye pille Comfortis til hunde værd? Lufenuron er den vej at gå? Her er de fordele og ulemper ved hvert produkt, og en, som du skal give din hund.

livscyklus loppe

For at forstå loppe piller skal du først forstå livscyklus en loppe.

En voksen loppe, som en, der kunne hoppe på din hund, når den er uden for eller kommer i kontakt med et angreb, kan lægge flere hundrede æg. Men for at udvikle de æg, der har brug for de næringsstoffer, der forekommer i blodet af dit kæledyr.

Efter bider og fodring på dit kæledyr (forårsager kløe), lægger æg. Disse æg kan lægges på dit kæledyr eller ud af vejen steder, hvor PET ophold (som i sin seng). Når æggene klækkes, de lever af affald og restprodukter til at blive en loppe moden, klar til at finde en mage og lidt blod.

Derefter starter hele processen igen.

Ikke kun lopper forårsage kløe og irritation for din hund, men kan også give problemer, såsom bændelorm - en bekymring og ekstra udgift til behandling.

Så den bedste måde at behandle lopper er at stoppe denne cyklus af liv.

Lufenuron plejede at være den aktive ingrediens i programsamarbejdslandene månedlige loppe piller. Dette var en første af sin slags oral medicin designet til at styre lopper.

Medicin (som også kom i flydende form) ikke behandler lopper lever, selv om. Det var designet til at styre lopper køber deres æg ikke-levedygtig. Så lopper lever ville gå gennem deres livscyklus, men ikke være i stand til at producere flere lopper.

Problemet med dette er, at hunden stadig kunne lider lopper for uger eller måneder efter pille blev administreret hvis huset have haft en loppeangreb. Meget ofte pille bør administreres med en aktuel medicin eller en anden pille at lindre hund og kontrol lopper.

Hvis hunden har været udsat for et nyt angreb (som da han gik en tur i skoven med sin ejer), så hele processen med lopper ville starte igen.

Så mens i nogle situationer loppe medicin kunne hjælpe med loppe problemer, som helt sikkert har sine begrænsninger.

Den bedste aspekt af produktet er, at det har været i håndkøb. Ejeren af hunden ikke behøvede at tage ham til dyrlægen for at få produktet.

Ny Lufenuron Pill

De fleste piller Lufenuron rådighed i dag indeholder to eller anbefale at dosere hunden med en ingrediens: Nitenpyram.

Nitenpyram er fundet på 24 timer i håndkøb loppe pille, Capstar ingrediens. Denne pille dræber alle voksne lopper, der lever på hunde i 24 timer.

Tanken er, at de to ingredienser arbejder sammen om at dræbe lopper. Men i virkeligheden din hund vil sandsynligvis stadig lider lopper for en periode, hvor indtagelse af dette lægemiddel. Det fungerer bedst, hvis hunden er i og ikke går ind i områder, hvor han kan få en ny udsættelse for lopper.

Fordele og ulemper ved Lufenuron

Comfortis til hunde

Således produktlinje loppe pille var klar til noget bedre. I de senere år har der vist sig en ny pille lopper: Comfortis.

Comfortis loppe piller indeholdende spinosad, som er en ingrediens, der dræber alle voksne lopper, der forsøger at bit hunden. P-piller fortsætter med at dræbe alle nye engagementer med lopper i en hel måned. Comfortis har revolutioneret den måde, hvorpå pillerne loppe arbejde og også kan anvendes til katte samt.

Pillen loppe kan også anvendes i kombination med en topisk medicin som loppe revolution. Dette er især nyttigt, hvis din hund lider af allergi eller irritation forårsaget af loppebid. Men hvis produktet vaskes væk under grooming, er hunden stadig beskyttet mod

Ulempen ved Comfortis er, at du kun kan få fra din dyrlæge gennem en recept. Så hvis din hund ikke er strøm i sine vaccinationer og dyrlæge besøg årligt, så vil du ikke være i stand til at få produktet.

Fordele og ulemper ved Comfortis

bivirkninger?

Når du vælger at give lægemidlet hund, enten i håndkøb eller recept, bør du tjekke med din dyrlæge og se for bivirkninger. Begge piller kan give maveproblemer og det anbefales, at du giver dem p-piller med mad.

For min hund, opdagede jeg, at det er nok en løs afføring eller to for dag eller to efter administration af p-piller. Ellers synes han ikke at have nogen negative virkninger og pillerne arbejdet på at dæmme op for endnu en dårlig loppeangreb.

bedste måder at give en pille til hunde Flea

Nogle hunde vil let spise noget, og de andre er meget krævende og mistænksom. Da begge piller anbefaler, at hunden har en fuld mave, så sørg for du spise før du giver dem p-piller. Du kan derefter prøve at sætte p-piller i lommen pille eller indpakning det i en smule "brød eller frokost kød. Ideen er at maskere således at hunden let acceptere det.

Hvis din hund stadig ikke tage, kan det også være jorden op i lidt "af dåsemad. Bare sørg for at spise det hele måltid, for at få den fulde effekt.

generelle henstilling

Med fremkomsten af de nye pille lopper, Comfortis, et mere effektivt produkt blev født. Det er værd at turen til dyrlægerne, især hvis du lider af en loppeangreb, der ikke ønsker at holde op.

Hvis en dyrlæge tur ikke er muligt, og du ønsker at prøve lufenuron, anbefaler jeg at købe nogle piller Capstar, til dem, der giver hunden hver par dage arbejde for at dræbe voksne lopper. Derudover kan du også købe aktuelt effektiv håndkøb, som Advantage og Revolution. Ved hjælp af disse i kombination med lufenuron kan være mere effektiv i det lange løb. Eller springe Lufenuron og bare bruge aktuel. Resultaterne kan ikke være meget anderledes.

Som altid, hvis du er i tvivl om, hvordan du håndterer din hund nogen medicin lopper, er det bedst at konsultere en autoriseret dyrlæge på de særlige behov i din hund.

Lopper burde ikke volde dig eller din hund frustration. Der er mange store muligheder derude, der kan gøre din hund og dit hjem loppe gratis!

en dyrlæge Forklare dyder Comfortis

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Label: COMFORTIS- spinosad tablet, chewable

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Drug Label Info

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More Info For This Drug

NDC (National Drug Code) - Each drug product is assigned this unique number which can be found on the drug's outer packaging." href="#">NDC Code(s): 0986-4221-06, 0986-4221-10, 0986-4222-06, 0986-4222-10, view more

Drug Label Information

Updated January 15, 2015

If you are a consumer or patient please visit this version.

For information on dogs, see reverse side.

Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

COMFORTIS (spinosad) is available in four sizes of chewable flavored tablets for oral administration to cats and kittens according to their weight. Each chewable flavored tablet is formulated to provide a minimum spinosad dosage of 22.5 mg/lb (50 mg/kg). Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa . Spinosyn A and spinosyn D have the chemical compositions 2-[(6-deoxy-2,3,4 tri-O-methyl-α-L-mannopyranosyl)oxy]-13- [[5 (dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]- 9 ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16btetradecahydro- 14-methyl-1H-as-indaceno[3,2-d] oxacyclododecin-7,15-dione and 2-[(6-deoxy-2,3,4-tri-Omethyl- α-L-mannopyranosyl)oxy] 13-[[5-(dimethylamino) tetrahydro-6-methyl-2H-pyran-2 yl]oxy]-9-ethyl-2,3,3a,5a,5b, 6,9,10,11,12,13,14,16a,16b tetradecahydro-4,14-dimethyl- 1H-as-indaceno[3,2 d]oxacyclododecin-7,15-dione, respectively.

COMFORTIS kills fleas and is indicated for the prevention and treatment of flea infestations ( Ctenocephalides felis ), for one month, on cats and kittens 14 weeks of age and older and two pounds of body weight or greater.

COMFORTIS is given orally once a month, at the minimum dosage of 22.5 mg/lb (50 mg/kg).

Do not use the dosing schedule below when administering COMFORTIS to dogs, as it can result in an overdosage.

*Cats over 24 lbs should be administered the appropriate combination of tablets.

Administer COMFORTIS with food for maximum effectiveness.

COMFORTIS is a chewable tablet that can be consumed by cats when offered by the owner just prior to or after feeding. Alternatively, COMFORTIS may be offered in food or administered like other tablet medications. COMFORTIS should be administered at monthly intervals.

If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed, administer COMFORTIS with food and resume a monthly dosing schedule.

Treatment with COMFORTIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with COMFORTIS should continue the entire year without interruption.

To minimize the likelihood of flea reinfestations, it is important to treat all animals within a household with an approved flea protection product.

There are no known contraindications for the use of COMFORTIS.

Not for human use. Keep this and all drugs out of the reach of children.

Use with caution with concomitant extra-label use of ivermectin (see ADVERSE REACTIONS).

The safe use of COMFORTIS in breeding, pregnant, or lactating cats has not been evaluated.

In a well-controlled US field study, which included a total of 211 cats (139 treated with COMFORTIS and 72 treated with an active topical control once a month for 3 treatments), no serious adverse reactions were attributed to the administration of COMFORTIS.

Percentage of Cats (%) with Adverse Reactions

Over the 3-month (3-dose) study, vomiting occurred on the day of or the day after at least one dose in 28.1% (39/139) of the cats treated with COMFORTIS and in 2.8% (2/72) of the cats treated with the active topical control. Three of the 139 cats treated with COMFORTIS vomited on the day of or the day after all three doses.

Two cats that received extra-label topical otic ivermectin on Day -1 of the field study developed lethargy on Day 1 after COMFORTIS administration on Day 0.

For technical assistance or to report suspected adverse drug events, contact Elanco Animal Health at 1-888-545-5973. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth

The primary target of action of COMFORTIS in insects is an activation of nicotinic acetylcholine receptors (nAChRs). Spinosad does not interact with known binding sites of other nicotinic or GABAergic insecticides such as neonicotinides, fiproles, milbemycins, avermectins, and cyclodienes. Insects treated with spinosad show involuntary muscle contractions and tremors resulting from activation of motor neurons. Prolonged spinosad-induced hyperexcitation results in prostration, paralysis, and flea death. The selective toxicity of spinosad between insects and vertebrates may be conferred by the differential sensitivity of the insect versus vertebrate nAChRs.

In a well-controlled laboratory study, COMFORTIS began to kill fleas 30 minutes after administration and demonstrated 98% effectiveness within 4 hours. COMFORTIS kills fleas before they can lay eggs. In a separate well-controlled laboratory study, COMFORTIS demonstrated 100% effectiveness on the first day following treatment and >90% effectiveness on Day 30.

If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment.

In a field study conducted in households with existing flea infestations, flea count reductions of 97.5% were observed one month after the first treatment and 99.3% after three monthly treatments with COMFORTIS. Cats with pre-existing signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis, and pruritus as a direct result of eliminating the fleas.

In a margin of safety study, COMFORTIS was administered orally to 14-week-old kittens at 1X, 3X, and 5X the upper half (75 – 100 mg/kg) of the therapeutic dose band for six monthly dosing intervals 28 days apart. Vomiting was observed across all groups, but was seen with greater frequency in cats in the treated groups; it did not increase with increasing doses. Loose stool was observed in all but the 3X treatment group. Food consumption was decreased in the 5X female cats. COMFORTIS was not associated with clinically significant changes in hematology, clinical chemistry, coagulation, or urinalysis parameters. Cats administered COMFORTIS once monthly for 6 months in the 3X and 5X dose groups demonstrated cytoplasmic vacuolation, consistent with phospholipidosis, in the liver, lung, and adrenal gland. The long term effects of phospholipidosis are unknown. The administration of COMFORTIS was not associated with any clinically significant, gross necropsy or histopathological changes.

In a well-controlled field study, COMFORTIS was administered safely in conjunction with other frequently used veterinary products, including tapeworm anthelmintics, antibiotics, and an approved heartworm preventative containing ivermectin. Hematology and clinical chemistry values were compared pre- and post-study and were unremarkable.

Store at 20 to 25˚C (68 to 77˚F), excursions permitted between 15 to 30˚C (59 to 86˚F).

COMFORTIS is available in four tablet sizes for use in cats: 90, 140, 270 or 560 mg. Each tablet size is available in color-coded packages of 6 tablets.

For information on cats, see reverse side.

Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

COMFORTIS (spinosad) is available in six sizes of chewable flavored tablets for oral administration to dogs and puppies according to their weight. Each chewable tablet is formulated to provide a minimum spinosad dosage of 13.5 mg/lb (30 mg/kg). Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa . Spinosyn A and spinosyn D have the chemical compositions 2-[(6-deoxy-2,3,4-tri-Omethyl- α-L mannopyranosyl)oxy]-13-[[5-dimethylamino)- tetrahydro-6 methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b, 6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl- 1H-as Indaceno[3,2-d]oxacyclododecin-7, 15-dione and 2-[(6-deoxy 2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]- 13-[[5 dimethylamino)-tetrahydro-6-methyl-2H-pyran-2-yl] oxy]-9 ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a, 16b tetradecahydro-4,14-dimethyl-1H-as-Indaceno[3,2-d] oxacyclododecin-7,15-dione, respectively.

COMFORTIS kills fleas and is indicated for the prevention and treatment of flea infestations ( Ctenocephalides felis ) for one month, on dogs and puppies 14 weeks of age and older and 3.3 pounds of body weight or greater.

COMFORTIS is given orally once a month, at the recommended minimum dosage of 13.5 mg/lb (30 mg/kg).

Do not use the dosing schedule below when administering COMFORTIS to cats, as it can result in an underdosage.

* Dogs over 120 lbs should be administered the appropriate combination of tablets.

Administer COMFORTIS with food for maximum effectiveness.

COMFORTIS is a chewable tablet and is readily consumed by dogs when offered by the owner just prior to feeding. Alternatively, COMFORTIS may be offered in food or administered like other tablet medications. COMFORTIS should be administered at monthly intervals. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed, administer COMFORTIS with food and resume a monthly dosing schedule.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.

There are no known contraindications for the use of COMFORTIS.

Not for human use. Keep this and all drugs out of the reach of children.

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with COMFORTIS (see POST APPROVAL EXPERIENCE ).

COMFORTIS is for use in dogs and puppies 14 weeks of age and older (see ANIMAL SAFETY ).

Use with caution in breeding females (see ANIMAL SAFETY ). Use with caution in dogs with pre-existing epilepsy (see ADVERSE REACTIONS ). The safe use of COMFORTIS in breeding males has not been evaluated.

In a well-controlled US field study, which included a total of 470 dogs (330 dogs treated with COMFORTIS and 140 dogs treated with an active control), no serious adverse reactions were observed with COMFORTIS. All reactions were regarded as mild and did not result in any dog being removed from the study.

Over the 90-day study period, all observations of potential adverse reactions were recorded. Reactions that occurred at an incidence > 1% within any of the 3 months of observation are presented in the following table. The most frequently reported adverse reaction in dogs in the COMFORTIS and active control groups was vomiting. The occurrence of vomiting, most commonly within 48 hours after treatment, decreased with repeated doses of COMFORTIS. Percentage of Dogs (%) with Adverse Reactions

a This number (n=139) is less than the total number of dogs in the safety population for the active control group (n=140) because one dog joined the study late and was only dosed at Month 3.

In US and European field studies, no dogs experienced seizures when dosed with COMFORTIS at the therapeutic dose range of 13.5-27.3 mg/lb (30-60 mg/kg), including 4 dogs with pre-existing epilepsy. Four epileptic dogs that received higher than the maximum recommended dose of 27.3 mg/lb (60 mg/kg) experienced at least one seizure within the week following the second dose of COMFORTIS, but no seizures following the first and third doses. The cause of the seizures observed in the field studies could not be determined.

The following adverse reactions are based on post-approval adverse drug event reporting. The adverse reactions are listed in decreasing order of frequency: vomiting, depression/lethargy, anorexia, ataxia, diarrhea, pruritus, trembling, hypersalivation and seizures.

Following concomitant extra-label use of ivermectin with COMFORTIS, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation.

Post approval experience continues to support the safety of COMFORTIS when used concurrently with heartworm preventatives according to label directions.

The primary target of action of COMFORTIS in insects is an activation of nicotinic acetylcholine receptors (nAChRs). Spinosad does not interact with known insecticidal binding sites of other nicotinic or GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins, and cyclodienes. Insects treated with spinosad show involuntary muscle contractions and tremors resulting from activation of motor neurons. Prolonged spinosad-induced hyperexcitation results in prostration, paralysis, and flea death. The selective toxicity of spinosad between insects and vertebrates may be conferred by the differential sensitivity of the insect versus vertebrate nAChRs.

In a well-controlled laboratory study, COMFORTIS began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours. COMFORTIS kill fleas before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0% to 99.8% were observed over the course of 3 monthly treatments with COMFORTIS. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating the fleas.

COMFORTIS was tested in pure and mixed breeds of healthy dogs in well-controlled clinical and laboratory studies. No dogs were withdrawn from the field studies due to treatment-related adverse reactions.

In a dose tolerance study, COMFORTIS was administered orally to adult Beagle dogs at average doses of up to 100 mg/kg once daily for 10 consecutive days (16.7 times the maximum recommended monthly dose). Vomiting was seen in 5 of 6 treated dogs during the first 6 days of treatment, usually within 2.5 hours of dosing. Treated females lost weight early in the treatment period, but their weights were similar to control dogs by the end of the 24-day study. COMFORTIS was not associated with any clinically significant changes in hematology, blood coagulation or urinalysis parameters; however, mild elevations in ALT occurred in all dogs treated with COMFORTIS. By day 24, ALT values had returned to near baseline levels. Phospholipidosis (vacuolation) of the lymphoid tissue was seen in all dogs treated with COMFORTIS, the long-term effects of which are unknown.

In a margin of safety study, COMFORTIS was administered orally to 6-week-old Beagle puppies at average doses of 1.5, 4.4, and 7.4 times the maximum recommended dose at 28-day intervals over a 6-month period. Vomiting was observed across all groups, including the control. Increased vomiting was observed at elevated doses, usually within 1 hour following administration. Vomiting at all doses decreased over time and stabilized when puppies were 14 weeks of age. The average daily and total weight gains of treated dogs were smaller than control dogs and were dose dependent. COMFORTIS was not associated with clinically significant changes in hematology, clinical chemistry, coagulation or urinalysis parameters. Phospholipidosis (vacuolation) of the lymphoid tissue was seen in some dogs in the 4.4X group and all dogs in the 7.4X group. The long term effects of phospholipidosis are unknown. Treatment with COMFORTIS was not associated with any other clinically significant adverse clinical observations, gross necropsy or histopathological changes.

In a reproductive safety study, COMFORTIS was administered orally to female Beagles at 1.3 and 4.4 times the maximum recommended therapeutic dose every 28 days prior to mating, during gestation, and during a six-week lactation period. No treatment-related adverse effects were noted for conception rates in the dams, or for mortality, body temperature, necropsy, or histopathology findings for the dams or puppies. One dam from each treatment group experienced early pregnancy loss and one additional high dose dam aborted late term. The treated dams experienced more vomiting, especially at one hour post-dose, than the control dams. Puppies from dams treated at 1.3 times the maximum recommended therapeutic dose had lower body weights than puppies from control dams. Although puppy mortality between treated and control dams was not different, the puppies from the treated dams experienced more lethargy (4.4X group only), dehydration, weakness and felt cold to the touch (4.4X group only) than puppies from control dams.

A pilot study without a control group was conducted to analyze milk from three lactating dogs treated with an experimental formulation of spinosad at 1.5 times the maximum recommended dose administered at day 28 of gestation and 24 hours prior to parturition. The data demonstrated that spinosyns were excreted in the milk of these dogs. Mortality and morbidity were greatest in puppies from the dam with the highest spinosyns level in milk. The spinosad milk: reference plasma exposure ratio calculated from this study ranged from 2.2 to 3.5.

In well-controlled field studies, COMFORTIS was administered safely in conjunction with other frequently used veterinary products, such as vaccines, anthelmintics, antibiotics, steroids, flea and tick control products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, and prescription diets. Changes in hematology, clinical chemistry and urinalysis values were compared pre- and post-study and were unremarkable.

Store at 20-25°C (68 -77°F), excursions permitted between 15 to 30°C (59 to 86°F).

COMFORTIS is available in six tablet sizes for use in dogs: 90, 140, 270, 560, 810 or 1620 mg. Each tablet size is available in color-coded packages of 6 tablets.

NADA #141-277, Approved by the FDA

Manufactured for Elanco Animal Health,

A Division of Eli Lilly and Company,

Indianapolis, IN 46285

Elanco, Comfortis and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

NDC 0986-4221-06 CA4221

NDC 0986-4222-06 CA4222

NDC 0986-4223-06 CA4223

NDC 0986-4224-06 CA4224

NDC 0986-4225-06 CA4225

NDC 0986-4227-06 CA4227

For information on dogs, see reverse side.

Your veterinarian has chosen to prescribe COMFORTIS to meet your flea treatment and prevention needs. Controlling fleas is important to the health of your cat. Please read this leaflet, which describes the proper use of COMFORTIS to treat and prevent flea infestations. If you have any questions about this information, please consult your veterinarian. Additional information can be found at www.comfortis.com.

What is COMFORTIS?

COMFORTIS is a chewable, flavored tablet that you give to your cat to kill fleas and prevent flea infestations for one month. COMFORTIS is for monthly use in cats and kittens 14 weeks of age or older and 2 pounds of body weight or greater.

Why has my veterinarian prescribed COMFORTIS?

Your veterinarian has provided this medication to either prevent a flea infestation or to treat an existing flea infestation on your cat.

What should I discuss with my veterinarian regarding COMFORTIS for my cat?

Your veterinarian is your cat's healthcare expert and can make the best recommendation for medications for your cat. This includes the prevention and treatment of parasites such as fleas that may cause conditions that include flea allergy dermatitis, anemia, and other flea-related problems.

Key points of your discussion may include the following:

Treatment with COMFORTIS may begin at any time of the year, preferably starting one month before fleas become active and continuing through the end of flea season. In areas where fleas may occur year-round, monthly treatment with COMFORTIS should continue the entire year without interruption.
If a dose is missed, administer COMFORTIS with food and resume a monthly dosing schedule.
To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.
COMFORTIS is not for use in humans. Like all medications, keep COMFORTIS out of reach of children.
Make sure your veterinarian is aware of all medications, including over-the-counter (OTC) medications, that you are giving to your cat.

How should I give COMFORTIS to my cat?

Give COMFORTIS with food for maximum effectiveness. COMFORTIS is a chewable tablet that can be consumed by cats when offered just prior to or just after feeding. Alternatively, COMFORTIS may be offered in food or administered like other tablet medications.

Give COMFORTIS to your cat once a month. To help you remember the monthly dosing schedule, stick-on labels are included for your calendar.

What if I give more than the prescribed amount of COMFORTIS to my cat?

COMFORTIS has been tested in many types of cats, and no severe adverse reactions have been reported. At elevated dose rates, the most severe adverse reaction observed was increased vomiting and loose stool. In the event of possible overdose, contact your veterinarian, who is the healthcare expert for your cat.

Should I restrict either my cat's activity or contact with my cat after the tablet is consumed?

Since COMFORTIS is an oral formulation, you may maintain normal activities and interactions with your cat.

How quickly will COMFORTIS kill fleas?

In a laboratory study, COMFORTIS started to kill fleas within 30 minutes and killed 100% of the fleas within 24 hours. COMFORTIS kills fleas before they can lay eggs.

Does seeing fleas on my cat mean that the treatment is not working?

COMFORTIS kills fleas before they can lay eggs when used monthly according to the label directions. Remember that all animals in the household should be treated with an approved flea product to help control the flea population.

Female fleas that are living on animals produce eggs that fall from the animal into their surroundings. These eggs hatch within a week; larvae then emerge and spin cocoons to become pupae. The entire life cycle can be completed in as little as 3 weeks, with new adult fleas emerging from the pupae to jump onto your cat. Because each female flea can lay up to 50 eggs per day, there is potential for a large build-up of eggs, larvae and pupae, resulting in a constant supply of new adults emerging in the cat's environment.

Regardless of the product used to kill the fleas, the cat can continue to be exposed to the fleas that live in the environment. If these fleas jump onto the cat, they will be killed by COMFORTIS.

If you see fleas on your cat within a month after your cat receives COMFORTIS, it is most likely that these are new fleas that have recently emerged from pupae and jumped onto the cat. These new fleas will be killed before they can produce eggs that contaminate the environment.

Is it safe to give my cat COMFORTIS?

COMFORTIS has been demonstrated to be safe in cats when used according to label directions. Safety was shown in cats and kittens 14 weeks of age and older, in multiple laboratory studies and a field study in household cats. The safe use of COMFORTIS in breeding, pregnant, or lactating cats has not been evaluated.

What side effects might occur with COMFORTIS?

Like all medications, sometimes side effects may occur. In some cases, cats vomited after receiving COMFORTIS. If vomiting occurs within one hour of administration, redose with another full dose. Additional adverse reactions observed in studies were lethargy, decreased appetite, weight loss, and diarrhea.

Can other medications be given while my cat is taking COMFORTIS?

Yes, COMFORTIS has been given safely with a wide variety of products and medications. Your veterinarian should be made aware of all medications, including over-the-counter (OTC) medications, that you are giving to your cat. For heartworm prevention, use products that are specifically prescribed by your veterinarian.

How should COMFORTIS be stored?

Store at 68 to 77°F (20 to 25°C). Temporary periods of time outside of this range between 59 to 86°F (15 to 30°C) are permitted.

If you have questions regarding the use of this product, consult your veterinarian, your cat's healthcare expert. Additional information can be found at www.comfortis.com.

For information on cats, see reverse side.

Your veterinarian has chosen to prescribe COMFORTIS to meet your flea treatment and prevention needs. Controlling fleas is very important to the health of your dog. Please read this leaflet, which describes the use of COMFORTIS to treat and prevent flea infestations. If you have any questions about this information, please consult your veterinarian. Additional information can be found at www.comfortis.com.

What is COMFORTIS?

COMFORTIS is a chewable, flavored tablet that you give to your dog to kill fleas and prevent flea infestations for one month. COMFORTIS are for monthly use in dogs and puppies 14 weeks of age or older and 3.3 pounds of body weight or greater.

Why has my veterinarian prescribed COMFORTIS?

Your veterinarian has provided this medication to either prevent a flea infestation or to treat an existing infestation on your dog.

What should I discuss with my veterinarian regarding COMFORTIS for my dog?

Your veterinarian is your dog's healthcare expert and can make the best recommendation for medications for your dog. This includes the prevention and treatment of parasites such as fleas that may cause conditions that include flea allergy dermatitis, anemia, and other flea-related problems. Key points of your discussion may include the following:

Treatment with COMFORTIS may begin at any time of the year, preferably starting one month before fleas become active and continuing through the end of flea season. In areas where fleas may occur year-round, monthly treatment with COMFORTIS should continue the entire year without interruption.
If a dose is missed, administer COMFORTIS with food and resume a monthly dosing schedule.
To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.
COMFORTIS is not for use in humans. Like all medications, keep COMFORTIS out of reach of children.

How should I give COMFORTIS to my dog?

Give COMFORTIS with food for maximum effectiveness.

Give COMFORTIS to your dog once a month. To help you remember the monthly dosing schedule, stick-on labels are included for your calendar.

What if I give more than the prescribed amount of COMFORTIS to my dog?

COMFORTIS has been tested in many types of dogs, and no severe adverse reactions have been reported. At elevated dose rates, the most severe adverse reaction observed was increased vomiting. In the event of a possible overdose, contact your veterinarian, who is the healthcare expert for your dog.

Should I restrict either my dog's activity or contact with my dog after the tablet is consumed?

Since COMFORTIS is an oral formulation, you may maintain

normal activities and interactions with your dog.

How quickly will COMFORTIS kill fleas?

In a laboratory study, COMFORTIS started to kill fleas within 30 minutes and killed 100% of the fleas within 4 hours. COMFORTIS kills fleas before they can lay eggs.

Does seeing fleas on my dog mean that the flea treatment is not working?

Female fleas that are living on animals produce eggs that fall from the animal into their surroundings. These eggs hatch within a week; larvae then emerge and spin cocoons to become pupae. The entire life cycle can be completed in as little as 3 weeks, with new adult fleas emerging from the pupae to jump onto your dog. Because each female flea can lay up to 50 eggs per day there is potential for a large build-up of eggs, larvae and pupae, resulting in a constant supply of new adults emerging in the dog's environment.

Regardless of the product used to kill the fleas, the dog can continue to be exposed to the fleas that live in the environment. When these fleas jump onto the dog, they will be quickly killed by COMFORTIS.

If you see fleas on your dog within a month after your dog receives COMFORTIS, it is most likely that these are new fleas that have very recently emerged from pupae and jumped onto the dog. These new fleas will quickly be killed before they can produce eggs that contaminate the environment.

Is it safe to give my dog COMFORTIS?

COMFORTIS has been demonstrated to be safe in pure and mixed breeds of healthy dogs when used according to label directions. Safety was shown in puppies 14 weeks of age and older and adult dogs in both laboratory studies and clinical field studies. You should discuss the use of COMFORTIS with your veterinarian prior to use if your dog has a history of epilepsy (seizures).

Is it safe to give my breeding dogs COMFORTIS?

Use with caution in breeding females. You should discuss the use of COMFORTIS with your veterinarian prior to use in breeding females. Safe use of COMFORTIS in male dogs intended for breeding has not been evaluated.

What side effects might occur with COMFORTIS?

Like all medications, sometimes side effects may occur. In some cases, dogs vomited after receiving COMFORTIS. If vomiting occurs within an hour of administration, redose with another full dose. During clinical studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. These reactions were regarded as mild and did not result in any dog being removed from the studies.

Since the introduction of COMFORTIS, additional side effects reported are incoordination, itching, trembling and seizures.

Can other medications be given while my dog is taking COMFORTIS?

Yes, COMFORTIS has been given safely with a wide variety of products and medications. Your veterinarian should be made aware of all products that you administered and/or intend to administer to your dog. For heartworm prevention, use products that are specifically prescribed by your veterinarian.

How should COMFORTIS be stored?

Store at 68-77°F (20-25°C). Temporary periods of time outside of this range between 59-86°F (15-30°C) are permitted.

If you have questions regarding the use of this product, consult your veterinarian, your dog's healthcare expert. Additional information can be found at www.comfortis.com.

For technical assistance or to report suspected adverse drug events, contact Elanco Animal Health at 1-888-545-5973.

For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth

Elanco, Comfortis and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

NDC 0986-4221-06 CA4221

NDC 0986-4222-06 CA4222

NDC 0986-4223-06 CA4223

NDC 0986-4224-06 CA4224

NDC 0986-4225-06 CA4225

NDC 0986-4227-06 CA4227

Principal Display Panel - 90 mg Blister Label

For Dogs, Puppies, Cats and Kittens

14 weeks of age and older

3.3-4.9 lb dogs and 2-4 lb cats

(Give with a meal)

Manufactured for Elanco Animal Health,

Indianapolis, IN 46285

Principal Display Panel - 90 mg Carton Label

6 CHEWABLE TABLETS

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

APPROVED BY FDA NADA 141-277 Elanco TM

Principal Display Panel - 90 mg Box Label

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

Principal Display Panel - 140 mg Blister Label

For Dogs, Puppies, Cats and Kittens

14 weeks of age and older

5-10 lb dogs and 4.1-6 lb cats

(Give with a meal)

Manufactured for Elanco Animal Health,

Indianapolis, IN 46285

Principal Display Panel - 140 mg Carton Label

6 CHEWABLE TABLETS

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

APPROVED BY FDA NADA 141-277 Elanco TM

Principal Display Panel - 140 mg Box Label

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

Principal Display Panel - 270 mg Blister Label

For Dogs, Puppies, Cats and Kittens

14 weeks of age and older

10.1-20 lb dogs and 6.1-12 lb cats

(Give with a meal)

Manufactured for Elanco Animal Health,

Indianapolis, IN 46285

Principal Display Panel - 270 mg Carton Label

6 CHEWABLE TABLETS

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

APPROVED BY FDA NADA 141-277 Elanco TM

Principal Display Panel - 270 mg Box Label

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

Principal Display Panel - 560 mg Blister Label

For Dogs, Puppies, Cats and Kittens

14 weeks of age and older

20.1-40 lb dogs and 12.1-24 lb cats

(Give with a meal)

Manufactured for Elanco Animal Health,

Indianapolis, IN 46285

Principal Display Panel - 560 mg Carton Label

6 CHEWABLE TABLETS

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

APPROVED BY FDA NADA 141-277 Elanco TM

Principal Display Panel – 560 mg Box Label

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older. For use in cats and kittens 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

Principal Display Panel - 810 mg Blister Label

For Dogs and Puppies

14 weeks of age and older

40.1-60 lb 810 mg

(Give with a meal)

Manufactured for Elanco Animal Health,

Indianapolis, IN 46285

Principal Display Panel - 810 mg Carton Label

6 CHEWABLE TABLETS

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

APPROVED BY FDA NADA 141-277 Elanco TM

Principal Display Panel – 810 mg Box Label

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

Principal Display Panel - 1620 mg Blister Label

For Dogs and Puppies

14 weeks of age and older

60.1-120 lb 1620 mg

(Give with a meal)

Manufactured for Elanco Animal Health,

Indianapolis, IN 46285

Principal Display Panel - 1620 mg Carton Label

6 CHEWABLE TABLETS

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

APPROVED BY FDA NADA 141-277 Elanco TM

Principal Display Panel – 1620 mg Box Label

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

KILLS FLEAS AND PREVENTS INFESTATIONS

For use in dogs and puppies 14 weeks of age and older.

Starts killing fleas in 30 mins.

Kills fleas before they can lay eggs

Give with a meal

spinosad tablet, chewable

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COMFORTIS- spinosad tablet, chewable

Number of versions: 6

COMFORTIS- spinosad tablet, chewable

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Comfortis kann Ihr Tier zu schaden, wГ¤hrend tГ¶ten FlГ¶he (Video)

ITOS schwer, Ihren Hund oder Katze Kampf gegen FlГ¶he zu beobachten. Das letzte, was Sie tun mГ¶chten, ist es, eine giftige Kragen auf sie auszuГјben, da sie enthalten meist Pestizide. GrГјnes Leben Experte Terri Bennett zeigt, wie Sie natГјrliche LГ¶sungen, die genauso gut arbeiten.

Comfortis wurde von vielen TierГ¤rzten als die Antwort auf dem Floh Problem so viele haben angeboten. Allerdings macht die Verpackung deutlich, das Produkt kГ¶nnte einige Hunde ernsthaft krank machen.

Pat Anthony / Tier Examiner

Wenn ein Floh prГ¤ventive wie Comfortis kann ein Hund krank machen, kГ¶nnen einige fragen, warum ein Tierarzt wГјrde es empfehlen. Nach der Verwendung von topischen Produkten fГјr die Jahre, einige haben festgestellt, die Produkte nicht scheinen, wie auch sie haben zu arbeiten. Das ist eine wirklich gute Frage, einen Tierarzt zu fragen.

Comfortis ist nicht das einzige Produkt, das Warnungen fГјhrt. Es ist ein Gift, das gegeben wird, so dass die Nutzer sollten sich der Gefahren bewusst sein. Alle diese Produkt tragen Warnungen, die Hunde- und Katzenbesitzer zu lesen und sorgfГ¤ltig zu prГјfen.

Im GesprГ¤ch mit einem Vertreter von Bayer, Hersteller von Advantix und Advantage, dieser Leser wurde gesagt, Hunde nicht schlieГџlich immun gegen die Vorteile eines solchen Produktes werden wie manche glauben. Vielleicht gab es Kaninchen in der Gegend, was zu einem Floh Problem wurden. Es scheint 2012 fГјr FlГ¶he war ein schlechtes Jahr Гјberall, auch Orte ohne Kaninchen.

Die Erkenntnis, dass GesprГ¤che war nicht dabei, mit dem Floh Situation zu helfen, Comfortis versucht. Ja, erbrach die Hunde. Im folgenden Monat wurde die Dosierung auf 2 separate Tagen. Die Hunde erbrachen wieder, aber offenbar nicht ganz so schlecht.

Forschung Гјber Comfortis werden die Leser, um Details zu einem Medikament, das von Haustieren gegeben ist, so dass Comfortis wird toleriert werden, fГјhren. Ein weiteres Medikament, dass Sie vielleicht nicht wollen, dass Ihr Hund zu haben, zur VerfГјgung, um ihnen etwas, das die FlГ¶he tГ¶ten tolerieren, kann aber Ihr Hund schaden.

Es gibt viele GrГјnde, warum einige fГјhlen Comfortis wurde verletzt oder ihre Hunde getГ¶tet. Einige fragen sich vielleicht, wenn ein Hund hat ein geschwГ¤chtes Immunsystem, kГ¶nnte ein Produkt wie Comfortis bringen das Tier zu seinem Ende. Vielleicht nur 100% gesunde Haustiere sollten Produkte wie Comfortis verwenden. Leser kГ¶nnen sich fragen, wie sie beginnen zu wissen, ob ihr Haustier gesund genug fГјr solche Produkte.

Die Macher von Comfortis sind die Details mit der Box mit den Pillen Гјber das, was Ihr Haustier passieren kГ¶nnte, wenn es Comfortis gegeben. Verwenden Sie diesen Link, um die Informationen online Гјber Erbrechen, Durchfall und Symptome Ihr Haustier mit Comfortis erleben anzuzeigen.

Comfortis kann sicher und problemlos zu einigen Hunden gegeben werden. Doch wie Hundebesitzer sehen ihren Hund schien ein wenig nГ¤her an den Tod, nachdem er Comfortis, nicht jeder ist glГјcklich Гјber diese Art der FlohbekГ¤mpfung.

Comfortis: Miljövänlig Flea Control Product Review

Comfortis ™ är den allra första FDA-godkända, tuggtabletter, nötkött smaksatt tablett som faktiskt dödar loppor och förebygger loppangrepp på hundar i 30 dagar. Comfortis innehåller den miljövänliga aktiv ingrediens, spinosad som kommer från en naturlig jord bostad bakterie som heter Saccharopolyspora spinosa, som uppges ha samlats in från marken ur en övergiven rom destilleriet av en vetenskapsman som var på semester på en karibiska ön tillbaka 1982. Comfortis är en miljövänlig loppor produkt som fungerar.

Loppor, dessa små skadedjur angriper både hundar, katter och kan invadera era hem om de lämnas obehandlade. Fleabites kan orsaka obehag för ditt husdjur, och alla konstant repor och klåda kan orsaka hudinfektioner, vilket kommer att leda till allergiska hudreaktioner. Loppor kan också orsaka andra sjukdomsalstrande organismer, inklusive bandmaskar. Det är mycket viktigt att bli av med loppor så snabbt som möjligt och förhindra att de återvänder till att ditt husdjur håller sig frisk. Loppor är en fruktansvärd plåga för din hund och om den inte behandlas, kan loppangrepp innebära allvarliga hälsorisker för dina husdjur.

Comfortis loppa medicinering för hundar erbjuder stora fördelar som kommer i en produkt: Börjar att döda loppor inom 30 minuter efter att p-piller till din hund.

Dödar loppor innan äggen kan läggas.

Varar för en full 30 dagar.

Innehåller en miljövänlig ingrediens loppa döda.

Comfortis kommer förpackad i en fyrkantig kartong med en sex-månaders leverans av doser loppa medicinering. Varje tablett är individuellt förpackad i en blister påse och du trycker ut ett piller från sin påse varje månad. De piller är nötkött smaksatt och rund och brunfärgat. Nötkött-smaken kommer att locka din hund att vilja äta detta piller och han kommer att tro att detta är en behandling för honom. Comfortis är avsedd för valpar och hundar i åldrarna fjorton veckor och upp och att se din hund får maximalt skydd måste Comfortis ges tillsammans med måltid.

Loppor har fortfarande att få på hunden innan de kommer att dö. Det finns ingen loppa förebyggande medicinering ute som kommer att hålla loppor helt utanför ett djur. Om det finns loppor i ditt hem eller trädgård, kommer de att vara på ditt husdjur. Om du äger en hund, då är det bäst att inte ta din hund på promenader, speciellt om du kämpar loppor redan. Ju mer du tar hunden på promenader, sedan fler loppor han kommer att få och kommer att fortsätta få fler loppor hem med varje promenad han får fortsätta.

Loppor tillbringar större delen av sin livscykel från djuren. Livscykeln för loppor börjar med ägg, som vänder sig till larver, sedan larver vänder sig puppa och sedan puppor vänder sig till den vuxna loppan. När en manlig och kvinnlig loppa ha sex (jag är inte säker på om det är missionär stil eller VOVVE stil), strax efter parning, dör den manliga loppor. Honan kommer att fortsätta mata ut ett djur smaska på blod i cirka 10 dagar. När hon är full, humle hon av djuret att gå lägga sina ägg. Under en period på cirka upp till fyra veckor, kan hon lägga tusen och tusentals ägg och när hon lägger alla ägg dör honan strax efteråt. Sedan hela fula livscykel börjar med alla andra vuxna loppor som är ute redan och har la sina ägg.

En sex-månaders leverans av Comfortis löper runt $ 85,00 genom en veterinär som är värt pengarna eftersom det fungerar som genomsnitt för att springa omkring $ 13,00 i månaden för loppor. Jag pratade med min hund veterinär häromdagen och receptionist och de båda säger att de använder Comfortis och kommer aldrig att använda något annat att kontroll loppor. De båda sa att de älskar det. . Vi administrerade en dos till min brorson hund igår och hittills är jag imponerad av denna loppor produkt! Jag hittade bara en loppa hittills och loppan knappt rör sig.

Följande information finns på baksidan av paketet: Comfortis tuggtabletter dödar loppor och indicerat för prevention och behandling av loppangrepp på hundar under en månad.

Jag ger Comfortis 5 stjärnor för en stor loppa förebyggande och loppangrepp produkt.

ELANCO

PACK 2 X COMFORTIS 425 MG FÜR HUNDE UND KATZEN 6 KAUTABLETTEN

Behandlung und Vorbeugung von Befall mit Flöhen

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