Bravecto für mittelgrosse Hunde
Bravecto für mittelgrosse Hunde may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Ingredient matches for Bravecto für mittelgrosse Hunde
Fluralaner
Fluralaner is reported as an ingredient of Bravecto für mittelgrosse Hunde in the following countries:
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Hazyland
Hazyland Border Collies & Biscuit
Drengene har haft Seresto halsbånd på siden begyndelsen af foråret for at undgå flåter. Det har fungeret ret godt. Indtil for et par dage siden, havde jeg kun fundet en tæge på Hero, siden de fik halsbåndene på .
Inden for de sidste par dage, har jeg imidlertid fundet 2 tæger på Hero, 1 på Biscuit og 1 på Beat. Det var for mange på for kort tid, så i morges kontaktede jeg dyrlægen og fik en snak med ham om andre muligheder.
Jeg har tidligere brugt Byvantic og været meget glad for det. Det har fungeret rigtig godt for mine hunde, men jeg har hørt om ret mange andre, der lige pludselig har reageret meget voldsomt på produktet med kløe og ubehag, så det er jeg også lidt bekymret over.
Dyrlægen foreslog et nyt produkt, Bravecto. Det er en tyggetablet, som hunden skal have en gang hver 12 uge – dvs. 2 gange i løbet af året, for at være beskyttet hele sommeren.
“Nu er kampen mod lopper og flåter blevet endnu nemmere og mere sikker for dig og din hund end hidtil. Én tyggetablet som din hund skal spise eller have sammen med en lille godbid, giver øjeblikkelig og vedvarende effekt mod lopper og flåter i 12 uger!
Tyggetabletten hedder BRAVECTO og smager af svinelever.
Da din hund blot skal have en pille hver 3. måned, skal du ikke behandle så ofte som pipetter med spot-on midler. Effekten af BRAVECTO forsvinder ikke, hvis du vasker din hund med shampoo, eller hvis den ofte svømmer i havet. Desuden risikerer du heller ikke at komme i berøring med det aktive stof som du gør ved pipetter, der gives på hudens overflade i nakken.
Tyggetabletten indeholder det nye aktive stof fluralaner, som giver hurtig og vedvarende effekt mod lopper (Ctenocephalised felis) og flåter (Ixodes ricinus, Dermacentor reticulatus, Dermacentor variabilis og Rhipicephalus sanguineus. OBS sidstnævnte beskyttes der mod i 8 uger og ikke 12 uger). BRAVECTO er også sikker at anvende til drægtige og diegivende tæver, samt til avlshanner og hunde af collieracer.”
Jeg besluttede at give det en chance, så nu har drengene fået hver en tablet. At de smager af svinelever er Beat nu ikke helt enig i! Hero og Biscuit var begejstrede for deres tablet, men Beat ville ikke røre sin lige meget hvordan jeg prøvede at præsentere den for ham, så til sidst måtte jeg bare brække den i små stykker og stoppe dem ned i halsen på ham. Det ville være rart, hvis man kunne få dem både som tyggetablet og almindelig tablet, så de hunde, der ikke falder for det med leversmagen, kunne få en mindre pille at sluge.
Nu er jeg spændt på at holde øje med tæge-situationen. Jeg håber, at dette nye præparat er lige så godt, som det lyder.
Bravecto
This is a summary of the European public assessment report (EPAR) for Bravecto. It explains how the Agency assessed this veterinary medicine to recommend its authorisation in the European Union (EU) and its conditions of use. It is not intended to provide practical advice on how to use Bravecto.
For practical information about using Bravecto animal owners or keepers should read the package leaflet or contact their veterinarian or pharmacist.
Bravecto is a veterinary medicine used to treat flea and tick infestations in dogs and cats. It may be used as part of the management of flea allergy dermatitis (an allergic reaction to flea bites). Bravecto contains the active substance fluralaner.
Bravecto is available as a spot-on solution in a pipette for use on dogs and cats and as chewable tablets for use in dogs. The spot-on solution and tablets are available in different strengths for dogs and cats of different weights.
The content of one full Bravecto pipette is applied to the dog or cat’s skin between the shoulder blades of the dog and at the base of the skull of the cat. For dogs several spots may be applied from the initial spot in a line to the base of the tail. The pipette to use is selected on the basis of the dog or cat’s weight. After being given its actions last for 12 weeks against fleas and ticks. Treatment should be repeated every twelve weeks for optimal flea and tick control.
Bravecto tablets are given around the dog’s feeding time as a tablet of the appropriate strength for the dog’s bodyweight. After being given its actions last for 12 weeks against fleas and 8 to 12 weeks against ticks. Treatment should be repeated every twelve weeks for optimal flea control. For optimal tick control treatment should be repeated every 8 to 12 weeks depending on the tick species.
Bravecto kills fleas within 8 hours and ticks within 12 hours in dogs. In cats, Bravecto kills fleas within 12 hours and ticks within 48 hours.
Bravecto can only be obtained with a prescription.
The active substance in Bravecto, fluralaner, acts as an ‘ectoparasiticide’. This means that it kills parasites that live on the skin or in the fur of animals, such as fleas and ticks. In order to be exposed to the active substance, fleas and ticks must attach to the skin and commence feeding on the dog or cat.
Fluralaner kills fleas and ticks that have ingested the dog’s or cat’s blood by acting on their nervous system. It blocks the normal movement of charged chloride particles (ions) in and out of nerve cells, especially those associated with gamma-aminobutyric acid (GABA) and glutamate, two substances that convey messages between nerves (neurotransmitters). This results in uncontrolled activity of the nervous system and the paralysis and death of the fleas and ticks. Fluralaner kills fleas before they can lay eggs and so helps to reduce contamination of the dogs’ or cats’ environment.
The effectiveness of Bravecto against fleas and ticks was investigated in both laboratory and field studies.
In an EU field study involving 561 dogs with flea and/or tick infestations the effects of Bravecto tablets were compared with those of another product, fipronil, that kills fleas and ticks, applied as a spot-on solution to the skin of the dogs. The main measure of effectiveness was the reduction in the number of fleas and ticks in the infested dogs during the 3 months after receiving treatment. The field study showed that Bravecto was effective in reducing the number of fleas and ticks in dogs with existing flea or tick infestations and that its effects against fleas and most tick species persisted for 3 months.
Two further EU field studies involved dogs and cats with flea and/or tick infestations and compared the effects of Bravecto spot-on solution with fipronil spot-on solution. Bravecto was effective against fleas and ticks for up to 12 weeks after treatment, and was as effective as fipronil in terms of the percentage of dogs and cats as well as households free of fleas and ticks.
The most common side effects of the tablets in dogs (which may affect more than 1 in 100 animals) are mild and short-lived diarrhoea, vomiting, lack of appetite and drooling.
The most common side effect of the spot-on solution (which may affect more than 1 in 100 animals) is a mild short-lived skin reaction at the application site, such as erythema (redness) and pruritus (itching) or hair loss.
Because fleas and ticks must start feeding on the dog in order to be killed by the medicine, they might still be able to transmit any diseases with which they may be infected.
For the full list of all side effects reported with Bravecto, see the package leaflet.
This product is harmful if swallowed. The product should be kept in the original package until use, in order to prevent children directly accessing the medicine. Suitable gloves should be worn when handling or giving Bravecto spot-on solution to dogs and cats. In case of spillage on table or floor surfaces, excess Bravecto spot-on solution should be removed using paper tissue and the area cleaned with a detergent.
People handling the medicine should not smoke, eat or drink and should wash their hands thoroughly after handling the product. Used pipettes should be disposed of immediately. If the product is accidentally swallowed by a person, the advice of a doctor should be sought immediately and the package leaflet or label shown to the doctor.
Bravecto spot-on solution and the wet skin of a recently treated animal may be slightly irritating to skin and/or eyes. Contact with skin and/or eyes should be avoided including hand to eye contact. Contact with the application site should be avoided until it is dry so it is recommended to apply to the animal in the evening. On the day of applying Bravecto spot-on solution treated animals should not be allowed to sleep in the same bed as their owner, especially children. In case of eye contact the affected area should be rinsed immediately with water.
Bravecto spot-on solution should be kept away from heat, sparks, open flames or other fire sources as it is highly flammable.
The Agency’s Committee for Medicinal Products for Veterinary Use (CVMP) concluded that Bravecto’s benefits are greater than its risks and recommended that it be approved for use in the EU.
The European Commission granted a marketing authorisation valid throughout the EU for Bravecto on 11 February 2014.
For more information about treatment with Bravecto, animal owners or keepers should read the package leaflet or contact their veterinarian or pharmacist.
This EPAR was last updated on 27/11/2017 .
Authorisation details
Product details
Publication details
Intervet International B.V
Contact address:
Intervet International B.V
Wim de Körverstraat 35
5831 AN Boxmeer
Product information
Product information
06/10/2017 Bravecto -EMEA/V/C/002526 -IB/0022
- Annex I - Summary of product characteristics
- Annex IIA - Manufacturing-authorisation holder responsible for batch release
- Annex IIB - Conditions of the marketing authorisation
- Annex IIIA - Labelling
- Annex IIIB - Package leaflet
Please note that the size of the above document can exceed 50 pages.
You are therefore advised to be selective about which sections or pages you wish to print.
Pharmacotherapeutic group
Ectoparasiticides for systemic use
Therapeutic indication
For the treatment of tick and flea infestations in dogs and cats.
The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Assessment History
Changes since initial authorisation of medicine
Initial marketing-authorisation documents
Authorised
This medicine is approved for use in the European Union
LOPPE- OG FLÅTMIDDEL 1000 MG
LOPPE- OG FLÅTMIDDEL 1000 MG
Handelsvilkår
Nedenstående vilkår er gældende for handel på www.petworld-vet.dk og hertil relaterede sider, som er drevet af
CVR: 31 41 20 48
Med fysisk forretningssted
Søren Nymarksvej 27
Tlf.: 72 73 12 50
I det følgende benævnt ”Petworld Vet”.
Fragt- og leveringsomkostninger
Under bestilling af varer, før betaling, vælges leveringsmetode. Det er muligt at vælge levering til døren, til pakkeshop eller til en af vores Petworld-butikker. Vi leverer med Brink Transport, DAO og Bring.
Petworld Vet leverer udelukkende til Danmark. Vi tilbyder GRATIS LEVERING til pakkeshops på langt hovedparten af vores produkter.
Pakker til hjemmelevering vil blive flexleveret og stilles uden kvittering. Ved flexlevering bærer kunden selv ansvaret for varens beskaffenhed, herunder sikkerhed og forsvarlig opbevaring.
Vi tilbyder GRATIS LEVERING til pakkeshops på langt hovedparten af vores produkter. Enkelte varer kan være undtaget for fragtfri levering uanset købsantal, her pålægges leveringsgebyr. Disse varer er markeret med en blå købsknap. Køber du dog andre varer for mere end kr 399,- vil den pågældende vare dog blive leveret fragtfrit.
Såfremt at fragtfri levering ikke opnås, beregnes fragtprisen som følger:
Petworld Vet har en målsætning om at afsende alle ordrer afgivet inden kl. 15.00 (14.00 såfremt levering er til pakkeshop) samme dag, som ordrerne er kommet ind - lørdage og helligdage dog undtaget. Levering vil som udgangspunkt ske hverdagen efter- Pt- bliver ca. 80% af alle ordrer afgivet inden kl. 15.00 (14.00 for levering til pakkeshop) afsendt samme dag. Alle ordrer afsendes indenfor 1-3 hverdage fra vores lager i Højbjerg. Ved levering til Bornholm og ikke-brofaste øer må der påregnes 1 ekstra leveringsdag.
Såfremt varen leveres i udhuse eller lignende, bærer kunden selv ansvaret for varens beskaffenhed, herunder transportskader og buler, samt sikkerhed og forsvarlig opbevaring.
Såfremt varen ønskes stillet i en opgang med dørtelefon, kan vi ikke garantere for sikker levering, da der er risiko for at varen bliver stillet udenfor på gadeplan. Vi anbefaler derfor, at pakken leveres til en alternativ adresse, hvis du bor i opgang med dørtelefon og ikke er hjemme til at modtage pakken. Levering er til gadedør i gadeplan.
Ved afhentning af varer i en fysisk Petworld-butik, skal du fremvise gyldigt billedlegitimation i forbindelse med udleveringen af de bestilte varer. Gyldigt billedlegitimation er pas eller kørekort.
Vi opfordrer vores kunder til at undersøge varen, når den er blevet leveret.
Faktura sendes til dig med mail, når vi afsender varerne fra vores lager. Du vil samtidig få en "Track & Trace" meddelelse, så du selv kan følge forløbet på din forsendelse, samt se hvor den befinder sig.
Når du handler på vores hjemmeside, kan du registrere dig som medlem via medlemscentret og optjene bonus og stempler på udvalgte varer. Som registreret medlem har du altid mulighed for indsigt, og du kan gøre indsigelse mod en registrering i henhold til reglerne i Persondataloven.
Ønsker du at annullere en ordre, kan dette ske inden dennes afsendelse fra Petworld Vet. Du kan således annullere de ordrer, der indeholder lagerførte artikler. Alle varer vist på shoppen er lagervarer. Annullering af ordrer kan foretages ved at skrive til kundeservice@petworld-vet.dk
På petworld-vet.dk kan du kun bestille varer via vores website. Hvis du har forespørgsler til varer, som ikke er på siden, er du velkommen til at kontakte os.
Medmindre andet er angivet, er alle angivne priser i danske kroner og inklusiv den til enhver tid gældende moms. I de angivne priser på levering i Danmark, er Danmark defineret som Jylland, Fyn, Sjælland samt brofaste øer. Priserne er dagspriser.
Når du handler med Petworld Vet indgås aftaler på dansk.
Hvis du ønsker, at modtage en kopi af din ordrebekræftelse, skal du sende en mail til kundeservice@petworld-vet.dk
Betaling for bestilte varer kan ske online ved brug af:
VISA- Master- samt Eurocard (dansk udstedt)
JCB (og andre udenlandsk udstedte kort)
Beløb trækkes først på din konto når fysisk afsendelse sker fra vort lager. Der kan aldrig trækkes et større beløb end det, du har godkendt ved købet.
Betalingsbetingelser for abonnement står nærmere beskrevet under punktet ”Petworld Vet-abonnement”.
Du har 14 dages fortrydelsesret, når du handler på petworld-vet.dk. Fortrydelsesfristen udløber 14 dage efter den dag du;
har modtaget din vare
får den sidste vare i fysisk besiddelse, når det drejer sig om en aftale om flere forskellige varer, som er bestilt i én ordre, og som leveres enkeltvis
får det sidste parti, eller den sidste del i fysisk besiddelse, når det drejer sig om en aftale om levering af en vare, der består af flere partier eller dele
Du skal inden 14 dage fra modtagelse give os meddelelse om, at du ønsker at fortryde dit køb. Meddelelsen skal gives skriftligt til enten vores postadresse eller kundeservice@petworld-vet.dk. I din meddelelse skal du gøre os tydeligt opmærksom på, at du ønsker at udnytte din fortrydelsesret. Du kan også vælge at benytte vores standardfortrydelsesformular og sende med retur. Standardfortrydelsesformularen finder du medsendt din elektroniske ordrebekræftelse og faktura samt via dette link: standardfortrydelsesformularen
Du kan ikke fortryde ved blot at nægte modtagelse af varen uden samtidig at give os tydelig meddelelse om dette.
Du skal sende din ordre retur til os uden unødig forsinkelse og senest 14 dage efter, du har meddelt os, at du ønsker at fortryde dit køb. Du skal afholde de direkte udgifter i forbindelse med tilbagelevering af varen. Ved returnering er du ansvarlig for, at varen er pakket forsvarligt ind. Du bærer risikoen for varen fra tidspunktet for varens levering.
OBS! Varer undtaget fortrydelsesretten
Følgende varetyper er undtaget fortrydelsesretten:
Levering af forseglede varer, som af sundhedsbeskyttelses- eller hygiejnemæssige årsager ikke er egnet til at blive returneret, og hvor forseglingen er blevet brudt efter leveringen, dette er eksempelvis loppemidler, kosttilskud mv.
Varens stand, når du sender den retur
Du hæfter kun for eventuel forringelse af varens værdi, som skyldes anden håndtering, end hvad der er nødvendigt for at fastslå varens art, egenskaber og den måde, den fungerer på. Med andre ord – du kan prøve varen på samme måde, som hvis du prøvede den i en fysisk butik.
Hvis varen er afprøvet udover, hvad der er beskrevet ovenfor, betragter vi den som brugt, hvilket betyder, at du ved fortrydelse af købet kun får en del eller intet af købsbeløbet retur, afhængig af varens handelsmæssige værdi.
For at modtage hele købsbeløbet retur må du altså gøre det samme, som man kan i en fysisk butik. Du må afprøve varen, men ikke tage den i brug.
Hvis du benytter din fortrydelsesret, refunderer vi alle betalinger modtaget fra dig, herunder leveringsomkostninger (dog ikke ekstra omkostninger som følge af dit eget valg af en anden leveringsform end den billigste form for standardlevering, som vi tilbyder), uden unødig forsinkelse og under alle omstændigheder senest 14 dage fra den dato, hvor vi har modtaget meddelelse om din beslutning om at fortryde denne aftale. Vi gennemfører en sådan tilbagebetaling med samme betalingsmiddel, som du benyttede ved den oprindelige transaktion, medmindre du udtrykkeligt har indvilget i noget andet.
Vi kan tilbageholde tilbagebetalingen, indtil vi har modtaget varen retur, med mindre du inden da har fremlagt dokumentation for at have returneret den.
Du vil modtage en mail, når vi modtager dine varer på vores adresse.
Søren Nymarksvej 27
Att.: Vet-kompagniet ApS
Varen kan også afleveres på Petworld Vet's faste forretningssted.
Hvad skal jeg sende med tilbage?
Du skal vedlægge en kopi af ordrebekræftelsen.
Bemærk! Vi modtager ikke pakker sendt pr. efterkrav.
OBS! Loppemidler kan ikke byttes eller returneres, også selvom pakken ikke har været åbnet. Dette skyldes loven om salg af lægemidler. Du kan få flere oplysninger ved at kigge på www.laegemiddelstyrelsen.dk eller ringe til dem på telefon 44 88 95 95.
OBS! Varer købt med gavekort kan ikke refunderes til et betalingskort eller konto.
OBS! Er du ikke hjemme ved levering, sker genudbringning for egen regning. Herudover vil du som kunde blive pålagt et gebyr for fragten retur til os.
Købelovens mangelregler kan finde anvendelse på varekøb.
I overensstemmelse med købelovens regler ydes du som forbruger 24 måneders reklamationsret på alle varer. Det betyder, at du enten kan få varen repareret, ombyttet, pengene tilbage eller afslag i prisen, afhængig af den konkrete situation. Det er selvfølgelig et krav, at reklamationen er berettiget, og at manglen ikke er opstået som følge af en fejlagtig brug af produktet eller anden skadeforvoldende adfærd. For varer med begrænset levetid er din reklamationsret dog begrænset til den holdbarhedsperiode, der er sædvanlig for den pågældende vare.
Opdager du fejl eller mangler ved en købt vare, skal du snarest muligt og inden for rimelig tid kontakte Petworld Vet og forklare, hvori fejlen eller manglen består. Reklamation kan foretages ved at kontakte os på kundeservice@petworld-vet.dk. Vi vil herefter sende dig en returlabel pr. mail som du skal printe ud og vedhæfte returforsendelsen. Alle henvendelser via mail vil blive besvaret senest den førstkommende hverdag. Alternativt kan varen tilsendes eller indleveres på adressen: Net K/S, att.: Petworld Vet, Søren Nymarksvej 27, 8270 Højbjerg, tlf. 72 73 12 50.
Du skal reklamere indenfor "rimelig tid" efter, at du har opdaget manglen ved varen. Hvis du reklamerer indenfor to måneder efter, at manglen er opdaget, vil reklamationen altid være rettidig.
Vælger du at sende returvaren uden tilsendte returlabel, vil vi refundere dig de rimelige omkostninger herfor, normalt DKK 49,-.
Varen sendes til:
Søren Nymarksvej 27
Att.: Vet-kompagniet ApS
Vi har brug for information i form af en faktura eller ordrebekræftelse på købet ved tilbagesendelse. Når du benytter dig af din reklamationsret, bedes du oplyse hvad problemet ved varen er så detaljeret som muligt.
Bemærk! Vi modtager ikke pakker sendt pr. efterkrav eller lignende.
Husk at varen altid skal sendes tilbage i forsvarlig emballage med din kvittering for afsendelsen, så vi kan tilbagebetale dine fragtomkostninger.
Alle ændringer i vores salgs- og leveringsbetingelser vil være tilgængelige på vores hjemmeside.
Med et Petworld Vet-abonnement kan du få leveret visse varer direkte til din dør. Du bestemmer selv hvor tit, og hvor meget du vil have leveret, og så sker levering helt automatisk. Abonnement kræver medlemskab af Club Petworld. Medlemskab er gratis.
Du optjener bonuspoint på hver handel.
Sådan forløber Petworld Vet-abonnementet:
Du kan tilmelde dig et Petworld Vet-abonnement gennem vores hjemmeside. Vi sender dig en bekræftelse via e-mail, når du bestiller dit abonnement.
Forinden levering sender vi en påmindelse, så du er forberedt på leveringen. Du skal senest to dage før levering kontakte kundeservice, såfremt du ønsker at ændre i dit abonnement.
To hverdage før afsendelsen af dine varer, reserverer vi den aktuelle dagspris på dit betalingskort.
Når varerne afsendes fra vores centrallager, vil den aktuelle dagspris blive hævet fra dit betalingskort. I samme forbindelse vil en kvittering blive fremsendt elektronisk til din e-mailadresse.
Levering sker på baggrund af de angivne leveringsbetingelser under disse vilkårs punkt 7.
Efter modtagelsen af varerne har du de samme beføjelser som alle vores andre kunder, dvs. at du naturligvis er velkommen til at returnere varerne eller reklamere over eventuelle mangler. For yderligere information henvises til disse vilkårs punkt 9 og 10.
Du kan til enhver tid pause eller opsige dit abonnement ved at logge ind via medlemscentret. Alternativt kan du kontakte kundeservice via kundeservice@petworld-vet.dk eller telefon 73 72 12 50 alle hverdage mellem 10-14. Du modtager en påmindelse forinden fremsendelsen af nye varer som led i abonnementsordningen, og du skal pause eller afmelde dit abonnement senest to hverdage inden afsendelsen af dine varer.
Betaling af dit Petworld Vet-abonnement:
Du kan udelukkende betale dit Petworld Vet-abonnement med betalingskort. Det er desværre ikke muligt at anvende Maestro. Hvis du ønsker at benytte et VISA Electron, er det en forudsætning, at kortet er godkendt til både e-commerce og tilbagevendende betalinger for at kunne tilmelde det vores abonnementsordning. Du kan tjekke med din bank, om dit VISA Electron kan anvendes.
Ved tilmelding skal du indtaste kortnummer, udløbsdato og kontrolcifre på det betalingskort, du ønsker at benytte. Du giver Petworld Vet tilladelse til at gemme betalingskortoplysningerne via AltaPay A/S, og accepterer således, at der er tale om en tilbagevendende betaling. I tilfælde af afmeldelse ved ferie og andet hæves der naturligvis ikke på kortet.
Det påhviler dig som kunde at sikre, at kortet er gyldigt og ajourført. Får du nyt kort, skal du huske at opdatere kortoplysningerne tilknyttet Petworld Vet-abonnementet. Dette gøres ved at kontakte Petworld-vet.dk via enten kundeservice@petworld-vet.dk eller via telefon 72 73 12 50 alle hverdage mellem 10-14. Når du vil ændre dine kortoplysninger bliver dit aktuelle abonnement slettet og et nyt oprettet, som du skal godkende med de nye kortoplysninger.
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Bravecto
This is a summary of the European public assessment report (EPAR) for Bravecto. It explains how the Agency assessed this veterinary medicine to recommend its authorisation in the European Union (EU) and its conditions of use. It is not intended to provide practical advice on how to use Bravecto.
For practical information about using Bravecto animal owners or keepers should read the package leaflet or contact their veterinarian or pharmacist.
Bravecto is a veterinary medicine used to treat flea and tick infestations in dogs and cats. It may be used as part of the management of flea allergy dermatitis (an allergic reaction to flea bites). Bravecto contains the active substance fluralaner.
Bravecto is available as a spot-on solution in a pipette for use on dogs and cats and as chewable tablets for use in dogs. The spot-on solution and tablets are available in different strengths for dogs and cats of different weights.
The content of one full Bravecto pipette is applied to the dog or cat’s skin between the shoulder blades of the dog and at the base of the skull of the cat. For dogs several spots may be applied from the initial spot in a line to the base of the tail. The pipette to use is selected on the basis of the dog or cat’s weight. After being given its actions last for 12 weeks against fleas and ticks. Treatment should be repeated every twelve weeks for optimal flea and tick control.
Bravecto tablets are given around the dog’s feeding time as a tablet of the appropriate strength for the dog’s bodyweight. After being given its actions last for 12 weeks against fleas and 8 to 12 weeks against ticks. Treatment should be repeated every twelve weeks for optimal flea control. For optimal tick control treatment should be repeated every 8 to 12 weeks depending on the tick species.
Bravecto kills fleas within 8 hours and ticks within 12 hours in dogs. In cats, Bravecto kills fleas within 12 hours and ticks within 48 hours.
Bravecto can only be obtained with a prescription.
The active substance in Bravecto, fluralaner, acts as an ‘ectoparasiticide’. This means that it kills parasites that live on the skin or in the fur of animals, such as fleas and ticks. In order to be exposed to the active substance, fleas and ticks must attach to the skin and commence feeding on the dog or cat.
Fluralaner kills fleas and ticks that have ingested the dog’s or cat’s blood by acting on their nervous system. It blocks the normal movement of charged chloride particles (ions) in and out of nerve cells, especially those associated with gamma-aminobutyric acid (GABA) and glutamate, two substances that convey messages between nerves (neurotransmitters). This results in uncontrolled activity of the nervous system and the paralysis and death of the fleas and ticks. Fluralaner kills fleas before they can lay eggs and so helps to reduce contamination of the dogs’ or cats’ environment.
The effectiveness of Bravecto against fleas and ticks was investigated in both laboratory and field studies.
In an EU field study involving 561 dogs with flea and/or tick infestations the effects of Bravecto tablets were compared with those of another product, fipronil, that kills fleas and ticks, applied as a spot-on solution to the skin of the dogs. The main measure of effectiveness was the reduction in the number of fleas and ticks in the infested dogs during the 3 months after receiving treatment. The field study showed that Bravecto was effective in reducing the number of fleas and ticks in dogs with existing flea or tick infestations and that its effects against fleas and most tick species persisted for 3 months.
Two further EU field studies involved dogs and cats with flea and/or tick infestations and compared the effects of Bravecto spot-on solution with fipronil spot-on solution. Bravecto was effective against fleas and ticks for up to 12 weeks after treatment, and was as effective as fipronil in terms of the percentage of dogs and cats as well as households free of fleas and ticks.
The most common side effects of the tablets in dogs (which may affect more than 1 in 100 animals) are mild and short-lived diarrhoea, vomiting, lack of appetite and drooling.
The most common side effect of the spot-on solution (which may affect more than 1 in 100 animals) is a mild short-lived skin reaction at the application site, such as erythema (redness) and pruritus (itching) or hair loss.
Because fleas and ticks must start feeding on the dog in order to be killed by the medicine, they might still be able to transmit any diseases with which they may be infected.
For the full list of all side effects reported with Bravecto, see the package leaflet.
This product is harmful if swallowed. The product should be kept in the original package until use, in order to prevent children directly accessing the medicine. Suitable gloves should be worn when handling or giving Bravecto spot-on solution to dogs and cats. In case of spillage on table or floor surfaces, excess Bravecto spot-on solution should be removed using paper tissue and the area cleaned with a detergent.
People handling the medicine should not smoke, eat or drink and should wash their hands thoroughly after handling the product. Used pipettes should be disposed of immediately. If the product is accidentally swallowed by a person, the advice of a doctor should be sought immediately and the package leaflet or label shown to the doctor.
Bravecto spot-on solution and the wet skin of a recently treated animal may be slightly irritating to skin and/or eyes. Contact with skin and/or eyes should be avoided including hand to eye contact. Contact with the application site should be avoided until it is dry so it is recommended to apply to the animal in the evening. On the day of applying Bravecto spot-on solution treated animals should not be allowed to sleep in the same bed as their owner, especially children. In case of eye contact the affected area should be rinsed immediately with water.
Bravecto spot-on solution should be kept away from heat, sparks, open flames or other fire sources as it is highly flammable.
The Agency’s Committee for Medicinal Products for Veterinary Use (CVMP) concluded that Bravecto’s benefits are greater than its risks and recommended that it be approved for use in the EU.
The European Commission granted a marketing authorisation valid throughout the EU for Bravecto on 11 February 2014.
For more information about treatment with Bravecto, animal owners or keepers should read the package leaflet or contact their veterinarian or pharmacist.
This EPAR was last updated on 27/11/2017 .
Authorisation details
Product details
Publication details
Intervet International B.V
Contact address:
Intervet International B.V
Wim de Körverstraat 35
5831 AN Boxmeer
Product information
Product information
06/10/2017 Bravecto -EMEA/V/C/002526 -IB/0022
- Annex I - Summary of product characteristics
- Annex IIA - Manufacturing-authorisation holder responsible for batch release
- Annex IIB - Conditions of the marketing authorisation
- Annex IIIA - Labelling
- Annex IIIB - Package leaflet
Please note that the size of the above document can exceed 50 pages.
You are therefore advised to be selective about which sections or pages you wish to print.
Pharmacotherapeutic group
Ectoparasiticides for systemic use
Therapeutic indication
For the treatment of tick and flea infestations in dogs and cats.
The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Assessment History
Changes since initial authorisation of medicine
Initial marketing-authorisation documents
Authorised
This medicine is approved for use in the European Union
Parasites & Vectors
Table of Contents
Efficacy of orally administered fluralaner (Bravecto TM ) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs
- Josephus J Fourie 1Email author ,
- Julian E Liebenberg 1 ,
- Ivan G Horak 2 ,
- Janina Taenzler 3 ,
- Anja R Heckeroth 3 and
- Regis Frénais 4
© Fourie et al.; licensee BioMed Central. 2015
Received: 22 December 2014
Accepted: 26 February 2015
Background
This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against naturally acquired generalized demodicosis in dogs.
Sixteen dogs, all diagnosed with generalized demodectic mange, were randomly allocated to two equal groups. Bravecto™ chewable tablets were administered once orally at a minimum dose of 25 mg fluralaner/kg body weight to one group of dogs, while the second group was treated topically on three occasions at 28-day intervals with Advocate® at a minimum dose of 10 mg imidacloprid/kg body weight and 2.5 mg moxidectin/kg body weight. Mites were counted in skin scrapings and demodectic lesions were evaluated on each dog before treatment and at 28-day intervals thereafter over a 12 week study period. Deep skin scrapings (
4 cm 2 ) were made from the same five sites on each dog at each subsequent examination.
After single oral administration of Bravecto™ chewable tablets, mite numbers in skin scrapings were reduced by 99.8% on Day 28 and by 100% on Days 56 and 84. Mite numbers in the dogs treated topically on three occasions at 28-day intervals with Advocate® were reduced by 98.0% on Day 28, by 96.5% on Day 56 and by 94.7% on Day 84. Statistically significantly (P ≤ 0.05) fewer mites were found on Days 56 and 84 on the Bravecto™ treated dogs compared to Advocate® treated dogs. A marked decrease was observed in the occurrence of erythematous patches, crusts, casts and scales in the dogs treated with Bravecto™ and in the occurrence of erythematous patches in the dogs treated with Advocate®. With the exception of one dog in each treated group, all dogs exhibited hair regrowth ≥ 90% at the end of the study in comparison with their hair-coat at study start.
Conclusions
Single oral administration of Bravecto™ chewable tablets is highly effective against generalized demodicosis, with no mites detectable at 56 and 84 days following treatment. In comparison, Advocate®, administered three times at 28-day intervals, is also highly effective against generalized demodicosis, but most dogs still harboured mites at all assessment time points. Both treatments resulted in a marked reduction of skin lesions and increase of hair re-growth 12 weeks after the initial treatment.
Background
Historically the only follicular mite considered to infest dogs is Demodex canis [ 1 ], but two other mites have subsequently been described. Desch and Hillier [ 2 ] described Demodex injai, a mite that is considerably longer than D. canis, while Tamura et al. [ 3 ] described a mite that is considerably shorter than D. canis, but failed to name it. In the literature this mite is now usually referred to as Demodex cornei. The three species differ in length as described by Izdebska and Fryderyk [ 4 ] with reference to average values. For D. canis adult female mites measured 226.0 μm and the males 195.2 μm. Adult female D. injai measured 330.9 μm and the males 371.8 μm. For D. cornei adult female mites measured 139.4 μm and the males 120.8 μm. Various molecular studies have been carried out to determine the specific identities of the three mites. Based on the results obtained from the mitochondrial markers 16S rDNA and Cytochrome Oxidase I (COI) for the three morphotypes of D. canis, De Rojas et al. [ 5 ] concluded that they are polymorphs of the same species. On the other hand phylogenetic analysis of the three species, based on partial sequences of mitochondrial 16S rDNA, led Sastre et al. [ 6 ] to propose that D. canis and D. injai are valid separate species and D. cornei a morphological variant of D. canis. A year later similar analyses performed by Milosevic et al. [ 7 ] confirmed that D. injai is a valid species. It is clear that further studies are required to ascertain the specific status of the mite referred to as D. cornei.
Demodex spp. mites (D. canis, D. injai, and D. cornei) are normal commensals of the dog’s skin parasitising within the sebaceous glands connected to the hair follicles. Should their numbers increase dramatically, they are capable of producing a disease known as canine demodicosis or demodectic mange. Canine demodicosis is an inflammatory parasitic skin disease that can be classified as localized or generalized according to the extent of the lesions. Localized demodicosis occurs as only small areas of alopecia, most commonly on the face and the forelegs. It is a benign disease and most cases resolve spontaneously within six to eight weeks. Demodicosis is considered generalized when five or more areas on the body are affected, or pododemodicosis is observed on two or more feet, or when an entire body region is involved [ 8 , 9 ]. Demodicosis can also be categorized as either juvenile (dogs up to 18 months of age), adult onset (dogs generally older than four years of age with no previous history of disease), or chronic generalized (persisting disease for at least six months) [ 10 , 11 ]. Susceptibility of dogs to infestations with Demodex spp. and to progression of the clinical disease are influenced by numerous factors including (listed in decreasing order of importance): immune status which may be affected by debilitating diseases, endoparasitism, breed, age as well as nutritional or hormonal status, other immunological disorders such as genetic defects and alteration of the skin’s biochemistry and structure [ 12 ]. Although D. canis remains the most common species/morphotype encountered in demodicosis, moderate alopecia, and greasy seborrhoeic dermatitis along the dorsal trunk of dogs has been associated with increased numbers of D. injai [ 13 ]. Moreover, bilateral ceruminous otitis in a beagle, of which D. injai was the cause, has been described [ 7 ]. D. cornei would appear to be an inhabitant of the host’s stratum corneum [ 5 ], and Shipstone [ 11 ] mentions that D. cornei has been found in association with a generalised, pruritic, scaly dermatitis, with the mites present in the surface scale.
Chronic generalized demodicosis is a frustrating and difficult skin disease to treat [ 14 - 16 ]. In dogs that are otherwise healthy, the generalized form of the disease is unlikely to resolve without therapy [ 10 ]. Therapeutic options that are currently available include amitraz, ivermectin, milbemycin oxime and moxidectin, mostly to be given at multiple occasions for periods of three months or more [ 16 - 18 ]. To be effective, these treatment regimens require high owner compliance over an extended period of time.
The active ingredient of Bravecto™, fluralaner, is a novel, long-acting systemic insecticide and acaricide belonging to the isoxazoline class of parasiticides with selective inhibition of arthropod γ–aminobutyric acid- and L–glutamate-gated chloride channels [ 19 ]. In field studies involving naturally infested dogs, a single oral administration of Bravecto™, formulated as a chewable tablet, proved to be > 99% effective against fleas and ticks at each measured time-point over a period of 12 weeks following treatment [ 20 ]. The dogs in these studies were variably infested with at least four tick species, including ticks belonging to the Rhipicephalus sanguineus group, Ixodes hexagonus, Ixodes ricinus and Dermacentor reticulatus. In a simulated home environment a single oral administration of Bravecto™ formulated as chewable tablets was > 99% effective against the flea Ctenocephalides felis, at every time-point measured over a period of 12 weeks following treatment [ 21 ]. In a laboratory study designed to detect the speed of kill of Bravecto™ chewable tablets against laboratory infestations of the tick I. ricinus on dogs, acaricidal efficacy was 89.6% at 4 hours, 97.9% at 8 hours and 100% at 12 and 24 hours after treatment [ 22 ]. An even faster onset of killing activity starting at 1 hour after oral administration of Bravecto™ chewable tablets was observed in dogs experimentally infested with C. felis flea [ 23 ]. The aim of the current study was to determine a) the efficacy of fluralaner against Demodex spp. mites and b) to show efficacy duration over 12 weeks following single oral treatment with Bravecto™ chewable tablets. As positive control, a second group of dogs was treated topically three times at a 28-day interval with Advocate® (imidacloprid and moxidectin).
Study design
In the present study, Bravecto™ administered as chewable tablets on a single occasion was the test product and Advocate®, administered three times at 28-day intervals was included as a positive control. This made it possible to compare the long term efficacy of 12 weeks of a single oral treatment with Bravecto™ chewable tablets against the efficacy of Advocate® administered at a 28-day interval according to the product label.
The study was designed as a parallel group, blinded, randomized, single centre, and positive controlled efficacy study. The study was conducted in accordance with the FDA Code of Federal Regulations: Good Laboratory Practice for Nonclinical Laboratory Studies 2009 [ 24 ], and all procedures were in compliance with South African National Standard “SANS 10386:2008: The care and use of animals for scientific purposes” [ 25 ]. The protocol was submitted to the ClinVet animal ethics committee that authorized the conduct of the study.
The test system was the individual dog. Dogs with natural infestations of Demodex spp. mites and presenting clinical signs of generalized demodicosis, e.g. erythema, hair loss, comedones, follicular casts and crusts were enrolled, with consent from their owners, in the study and were returned to their owners on completion of the animal phase. Dogs included in the study were mostly mongrels and of both sexes, older than 12 months, weighed between 3.5 and 13.7 kg, and except for clinical signs of generalized demodicosis, the dogs were healthy and as far as could be determined the dogs had not been treated with a glucocorticoid or any product with a miticidal effect for at least 12 weeks prior to inclusion. Additional requirements for inclusion were that deep skin scrapings performed before treatment had to be positive for Demodex spp. mites.
Sixteen dogs (7 male and 9 female), ranked within sex in descending order of individual pre-treatment mite counts were included in the study and allocated to two equal groups. Each dog was housed individually for the duration of the study in an indoor/outdoor run, without contact between animals, and was fed once a day according to the food manufacturer’s recommendations. Potable municipal water was available ad libitum.
Each dog was acclimatized to the housing and maintenance conditions for at least 14 days before treatment. As a precautionary measure all dogs were treated subcutaneously with an antibiotic (cefovecin), appropriate for the treatment of pyoderma on Days −14, −1, 13 and 27. Additionally, on Days −14 and 27, deep skin biopsies were taken from each dog after sedation. The biopsies indicated that exudative pyoderma was present in two dogs in each group on Day −14 and that it had cleared by Day 27. Chronic dermatitis, epidermal acanthosis and hyperkeratosis was present and unchanged in all dogs on both occasions. No inflammatory cells or bacteria were observed in the Day 27 biopsies and antimicrobial therapy was discontinued. Twice during acclimatization (Day −14 and Day −1) and on Days 27/28, 56 and 84 after treatment each dog was clinically examined by a veterinarian.
The dogs were weighed on a calibrated and verified electronic scale on Days −2, 13, 27, 41, 55, 69 and 84 for dose calculation for treatment, for the use of sedatives for skin scrapings and to document the body weight during the study period. General health observations were performed daily throughout the complete study period.
On Day 0, dogs of one group were treated once orally with Bravecto™ chewable tablets (fluralaner, 13.64% w/w), based on the dog’s individual body weight, to achieve a minimum dose of 25 mg/kg body weight and an efficacy over 12 weeks following treatment. The tablet(s) was (were) administered 20 (±10) minutes after food had been offered by placement in the back of the oral cavity over the tongue to initiate swallowing. Also on Day 0, commercially available Advocate® (imidacloprid, 10%/moxidectin, 2.5% w/v) was administered topically to the other group of dogs (positive controls) according to the product label. Due to the 28 days efficacy duration of Advocate®, these dogs were re-treated on Day 28 and 56. With the dog in a standing position, the coat was parted until the skin was visible and the Advocate® was administered directly onto the skin. Both treated groups were observed prior to treatment and again hourly for 4 hours after treatment of the last animal, for possible adverse events. Personnel performing the post-treatment observations were blinded with respect to the treatment.
Mite assessments
Deep skin scrapings (
4 cm 2 ), in which the skin was squeezed and scraped until capillary oozing was seen, were made from five sites on each dog on Days −4, 28, 56 and 84. Skin scrapings of the dogs treated with Advocate® were performed on Day 28 and Day 56, before the second or third treatment was applied, respectively. The same sites and/or sites of new lesions were scraped at each subsequent examination. Each scraping was transferred to a separate labelled microscope slide containing mineral oil and was examined under a stereomicroscope for the presence of Demodex spp. mites. The numbers of mites counted in each scraping were recorded separately.
Skin and hair assessments
The clinical signs and the extent of demodectic lesions on each dog were assessed on the days when skin scrapings were made, and recorded on a standardised form. The following parameters were assessed and sketched on a silhouette (left and right hand side) for each dog: body areas exhibiting erythema; body areas covered by casts, scales and crusts; body areas with hair loss. A semi-quantitative assessment of hair re-growth was performed, comparing hair coat before, within and after the 12 weeks study duration and assessed as percentage hair re-growth (0-50%, 50-90% or > 90%) defined as estimated percentage of hair cover growth compared to baseline total hairless area as assessed prior to veterinary product administration. Colour photographs illustrating the extent of lesions and their resolution were taken of each dog on Day −4 and subsequently at approximately monthly intervals up to Day 84 after treatment.
Efficacy evaluation
The primary assessment variable in the study was the decrease in total number of mites counted in skin scrapings following treatment.
where Mpre was the mean number of pre-treatment mite counts, and Mpost the mean number of post-treatment mite counts.
Additionally, the groups were compared using an ANOVA with a treatment effect after a logarithmic transformation on the mite (count + 1) data, for each study day.
On Day 50 one of the dogs in the group treated with Advocate® developed severe oedema of the left hind leg and prepuce and the swelling did not dissipate with antibiotic, diuretic and corticosteroid treatment. The dog was removed from the study on Day 59, sedated and upon laparotomy a large nodular tumour compatible with malignant lymphoma was found attached to the ventral spine, and the dog was euthanised during surgery. The results pertaining to this dog until Day 56, before its exclusion from the study on Day 59, have been included with those of the other dogs in the group treated with Advocate®.
No adverse event considered to be related to oral treatment with Bravecto™ chewable tablets or topical treatment with Advocate® was observed in any dog.
Geometric mean reductions in Demodex spp. mite counts of dogs treated once orally with Bravecto ™ or topically on three occasions at 28-day intervals with Advocate®
Mean a mite counts (n)
Mean a mite counts (n)
Mean a mite counts (n)
Mean a mite counts (n)
a Geometric mean.
b Mite counts calculated without one dog, which was euthanized on Day 59.
c Not applicable.
Reduction in the occurrence of dermatologic changes in dogs with generalized demodicosis after treatment with either Bravecto™ or Advocate®
Bravecto ™ : occurrence of lesions on days before and after treatment (dogs were treated on Day 0: number of dogs/number of dogs per group)
Crusts, casts or scales
Advocate®; occurrence of lesions on days before and after initial treatment (dogs were treated on Days 0, 28 and 56 a : number of dogs/number of dogs per group)
Crusts, casts or scales
a Skin assessments were performed before treatment.
b On day 59 one dog had to be euthanized due to the presence of a malign tumour in the stomach.
Hair re-growth on dogs with generalized demodectic mange after treatment with Bravecto™ or Advocate®
a Percentage hair re-growth defined as estimated percentage of hair cover growth compared to baseline total hairless area as assessed prior to veterinary product administration.
b Dogs were treated once orally on Day 0.
c Dogs were treated topically on Day 0, on Day 28 and again on Day 56. Hair assessments were performed before treatment.
d On day 59 one dog had to be euthanized due to the presence of a malign tumour in the stomach.
Example of hair re-growth in a dog suffering from generalized demodicosis pre-treatment (a) and 12 weeks after initiation of treatment (b).
The body weight of every dog increased similarly in both groups during the study period.
Discussion
A single oral administration of Bravecto™ chewable tablets to dogs with naturally acquired generalized demodicosis resulted in significantly lower mean mite counts 56 and 84 days after treatment and a correspondingly greater efficacy at each time period compared to three successive treatments with Advocate® at an interval of 28 days. No mites were present in the skin scrapings of the dogs 56 or 84 days after treatment with Bravecto TM chewable tablets, while a few mites were still present in skin scrapings 56 (mite average: 18.5) and 84 (mite average: 25.6) days after the initial treatment with Advocate®.
Reduction of mite counts was consistent with reduction in the extent and severity of the skin changes. Both groups of dogs showed resolution of the associated dermatologic signs with steady improvement over the 12 week treatment period. More Bravecto™ treated dogs had resolution of crusts, casts and scales and showed hair re-growth, while none of the Advocate® treated dogs had erythema at the assessment time point Day 84.
A problem frequently encountered with the treatment of demodicosis in dogs is the inability to ensure that a dog is absolutely free from mites after completion of a specific treatment regimen and re-infestation can be detected months after a treatment that was initially considered to be successful [ 15 , 16 ]. The present results are, however, encouraging that the administration of Bravecto™ chewable tablets offers the potential to provide sustained control of demodex mite infestations in susceptible dogs for at least three months after a single treatment.
Owner compliance can be an important factor in treatment success when multiple doses of a treatment spread over a long period of time are required in order to achieve a satisfactory outcome. Bravecto™ administered once as chewable tablets is not only effective against Demodex spp. mites on dogs but remains effective for 12 weeks following treatment. Moreover, it is effective for the same period of time against ticks and fleas that may concomitantly infest these animals [ 20 , 21 ]. Therefore, the single administration may help to reduce the risk of treatment failure as a consequence of poor owner compliance with treatment recommendations.
Bravecto™ chewable tablets have proved to be safe for use in dogs at five times the recommended therapeutic dose [ 26 ]. It is also safe to use in breeding, pregnant and lactating dogs. With this in mind it could prove to be an effective prophylactic intervention against the transmission of Demodex spp. mites from a post-parturient bitch to her new-born pups aiding in the prevention and control of demodicosis in all its forms on the following generation of dogs.
Conclusions
Single oral administration of Bravecto™ chewable tablets is highly effective against generalized demodicosis, with no mites detectable at 56 and 84 days following treatment. In comparison, Advocate®, administered three times at 28-day intervals, is also highly effective against generalized demodicosis, but most dogs still harboured mites at all assessment time points. Both treatments resulted in a marked reduction of skin lesions and increase of hair re-growth 12 weeks after the initial treatment.
Declarations
Acknowledgements
The authors would like to thank all the staff at ClinVet SA for their assistance and contribution to perform the study.
Competing interests
JF and JL are employed at ClinVet and IH is employed at the Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa. RF is employed at MSD Animal Health Innovation SAS, France and AH and JT are employed at MSD Animal Health Innovation GmbH, Germany.
The study was conducted as part of a research program to evaluate the efficacy of fluralaner for the treatment of generalized demodicosis in dogs compared to a positive control product.
Authors’ contributions
The study design, protocol and report of the study were prepared by RF, JF and JL, and reviewed by AH and JT. JL, JF and their team at ClinVet SA were responsible for the animal phase, data collection and statistical calculations. IH and JF were responsible for compiling the first draft of the manuscript. All authors revised and approved the final version.
Authors’ Affiliations
References
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Bravecto - er der nogen der kender dette produkt? <>
Personligt syntes jeg det virker tiltalende. og min hvalp har fået det. Han spiste den med glæde, så nu må vi se om den holder flåter og lopper væk
Både lopper og flåter skal bide for at de indtager stoffet, men de skulle gerne side så kort tid at der ingen risiko er for hunden for overførsel af sygdomme. Og lopperne kan ikke nå at ligge æg.
Jeg valgte det fordi jeg ikke skal tage hensyn til hvornår jeg kan smide diesel i bad, jeg slipper for at dryppe i nakken og det holder længe!.
Det er en rimelig stor fordel til brug ved en kommende udstillingshund
Der er kun 1 tabl. i pakken, men denne holder jo så 12 uger.
Det er lidt dyrere end det practic vi bruger nu. Men en del nemmere selvfølgelig
Så må jeg lige høre dyrlægen
Men ved bravecto skal de bide før de dør. De falder så af inden der er gået et døgn. Dvs inden de kan nå at overføre sygdomme. Så vidt jeg ved er bayvantic det eneste flåtmiddel hvor flåterne IKKE skal bide for at de dør..
@Trine: Det er altså ikke helt sandt det du siger med at det fx ikke vil koste Novo ekstra at få godkendt et præperat til en anden indikation end den oprindelige. Det kræver faktisk at man går hele møllen igennem med ny protokol, der skal sendes til myndighederne i de lande, man vil søge at få det godkendt i, nye kliniske studier og nye analyser af de data man får indsamlet. Man KAN være heldig at de vil acceptere de allerede lavede kliniske studier hvis det er sådan har indsamlet relevant data i dem.
Mht at man godt kan lave det billigere: Tjaeee, men det er jo sådan at et successfuldt produkt er det der skal betale for de næste mange mange års forskning og udvikling af nye produkter. Det er jo sådan at på et eller andet tidspunkt udløber patentet og så stor kopiproducenterne på spring for at lave det samme og sælge til en billigere penge. Kopiproducenterne har jo ingen udgifter på forsking og udvikling. Jeg arbejder selv med biostatistik fra kliniske studier i en lægemiddelvirksomhed, der er fondsejet. Dvs. vi har ingen aktionære der skal tjene på det. Det gør det hele lidt anderledes, men det er jo ikke sådan at der ikke skal tjenes penge; der skal være en temmelig stor pengetank til at holde en medicinalvirksomhed kørende og fortsætte med at lave forsøg og kliniske studier også i perioder, hvor der ikke er så stor indtjening pga fx patentudløb og konkurrence fra kopimedicin. Alle vil jo hele tiden have at der udvikles ny medicin med fx bedre effekt og færre bivirkninger. Og det er altså ikke dem der bare laver kopipræperater der kommer med den udvikling.
Nu har jeg selv også en baggrund fra at arbejde med virksomheder der markedsfører lægemidler - men har mest beskæftiget mig med den onkologiske verden. En af de ting jeg spørger mig selv om er - hvad dælen gør jeg hvis min hund får nogle af de bivirkninger som der er beskrevet for Bravecto - Jeg mener har i set halvveringstiden? (hvor lang tid det er i kroppen og virker, før det er brudt ned) Her tænker jeg at et overfladeprodukt vel altid kan vaskes af eller?
Jeg hører, at et konkurrerende firma, har lavet en lignende pille, der kun virker en måned. Den tror jeg , at jeg vil prøve i stedet for. For det er lang tid, at skulle have gener, hvis der er bivirkninger. Jeg ved ikke hvad det koster, men pipetter er også dyre, og der er ikke altid den optimale virkning, og hunde som tit er våde, vasker det af.(og så var der lige det med kramper)
Men synes det er mega skræmmende, at det stadig er aktivt på flåter. Og det må det være, når det er alle tre der har døde siddende.
Er der andre der har haft samme erfaring.
Min ene er dog begyndt at slikke sig ekstremt meget på kroppen nogle steder.
Er gået igang med allergifoder i samarbejde med dyrlægen, da der blev mistænkt foderallergi.
Lidt skræmmende at det lyder til at være i kroppen så længe
Jeg var lidt bekymret over at give det til Barley, da han tidligere har reageret dårligt på pipetterne. Jeg har så i mellemtiden fundet ud af, at det sandsynligvis er et bindemiddel i pipetterne, der udløste reaktionen.
Gruden til at du ikke finde kravlene flåter når hunden får bayvantic er pga. en såkaldt hot-feet-effekt som får huden til at brænde under fødderne på flåten, således at den falder af og dør. inden den når at bide.
Jeg har ikke noget i mod at skulle give dem med kortere intervaller, når den samlede "giftmængde" falder markant.
Bravecto - er der nogen der kender dette produkt?
De 7 bedste midler mod lopper og flåter
Der er mange produkter på markedet der kan behandle og forebygge mod lopper og flåter. Men det kan være svært at vurdere og vælge hvilket produkt der passer bedst til dig og dit kæledyr.
Derfor har vi lavet en liste over de 7 bedste midler mod lopper og flåter, som vi oftets anbefaler.
Frontline Pour-on Vet:
Til kat eller hund?: Behandling mod lopper og flåter til både hunde og katte
Produkt type: Pipette med dråber der skal gives direkte på huden
Hvor længe virker det mod lopper: Lopper dør inden for 24 timer og det virker i op til 8 uger for hunde og 4 uger for katte
Hvor længe virker det mod flåter: Flåter dør inden for 48 timer og virker i op til 4 uger hos hund og 2 uger for katte
Dyrlægens anbefaling om hvornår du skal vælge frontline Pour-on Vet:Frontline har i efterhånden en del år været er et godt valg mod både flåter og lopper og er det stadigt. Det dræber parasitterne hurtigt og sikkert. Tåles både af hund og kat, kort sagt er det effektivt, trygt og enkelt.
Frontline Combo Vet:
Fuldstændig som Frontline Pour-on Vet
Dyrlægens anbefaling om hvornår du skal vælge frontline Combo Vet: Frontline Combo Vet virker som Frontline Pour-on Vet men samtidig virker det også på umodne loppestadier i dyrenes omgivelser – dvs. æg og larver kan ikke udvikle sig til voksne lopper. Det betyder at du hurtigere kan komme af med lopperne.
Bayvantic Vet
Til kat eller hund?: Kun til hunde
Produkt type: Pipette med dråber der skal gives direkte på huden
Hvor længe virker det mod lopper: Lopper dør inden for 24 timer og det virker i op til 8 uger.
Hvor længe virker det mod flåter: Flåter dør inden for 24 timer og virker i op til 4 uger.
Dyrlægens anbefaling om hvornår du skal vælge Bayvantic Vet til hunde: Bayvantic forebygger og behandler også mod pelslus, sandfluer og myg. Derfor er Bayvantic loppe/flåtmiddel særlig velegnet hvis du skal have din hund med på ferie syd på. I de sydlige egne findes der stikkende myg og fluer der kan overføre nogle alvorlige sygdomme, som vi heldigvis ikke har i Danmark.
Bravecto (receptpligtig)
Til kat eller hund?: Kun til hunde
Produkt type: Tyggetablet med smag (som hunde godt kan lide)
Hvor længe virker det mod lopper: 3 måneder
Hvor længe virker det mod flåter: 3 måneder
Dyrlægens anbefaling om hvornår du skal vælge Bravecto: Hvis din hund tit bliver vasket eller hvis den bader i søer/hav meget tit. Eller hvis du ikke bryder dig om at dryppe den i nakken. Du skal være opmærksom på at lopper og flåter først dør efter de har bidt hunden, indenfor 12 timer. Og så skal du være opmærksom på at Bravecto er receptpligtigt.
Nexgaard tabletter (receptpligtig)
Til kat eller hund?: Behandling er kun til hunde
Produkt type: Tygge Tablet
Hvor længe virker det mod lopper: 5 uger
Hvor længe virker det mod flåter: 4 uger
Dyrlægens anbefaling om hvornår du skal vælge Nexgard. Nexgard er en tablet til hunde, der bekæmper lopper og flåter ved at give en tyggetablet een gang om måneden. Nexgard virker hurtigt mod lopper (inden for 8 timer) og virkningen holder i 4 uger, Nexgard dræber flåter og effekten holder i 4 uger. Flåter og lopper skal suge blod for at få det aktive stof i sig. Det dræber lopperne og flåterne, hvorefter de falder af hunden.
Da Nexgard gives i munden, kan hunden bade med det samme før og efter behandlingen. Nexgard er receptpligtigt.
Forskellen på Bravecto og Nexgard, der begge er tyggetabletter til hunde, er mængden af det aktive stof i produkterne. Der er betydelig større mængde i Bravecto og derfor holder virkningen længere.
Comfortis tabletter (receptpligtig)
Til kat eller hund?: Behandling til både katte og hunde
Produkt type: Tygge Tablet
Hvor længe virker det mod lopper: 4 uger
Hvor længe virker det mod flåter: Det virker kun mod lopper.
Dyrlægens anbefaling om hvornår du skal vælge Comfortis. Comfortis er en tabl behandling til både hund og kat til bekæmpelse at lopper. Produktet er velegnet hvis du ikke har behov for at forebygge mod flåter og du synes det er vanskeligt at behandle med pour-on produkterne. Det giver ikke fedtede mærker på pels eller i møbler og kan kæles, børstes eller bades væk. Comfortis skal gives en gang om måneden og er en tyggetablet med kødsmag der er nemt at give til dit kæledyr. Comfortis er receppligtigt.
Capstar tabletter
Til kat eller hund?: Behandling til både katte og hunde som kortvarigt har været i kontakt med lopper
Hvor længe virker det mod lopper: 24 timer
Hvor længe virker det mod flåter: 24 timer
Dyrlægens anbefaling om hvornår du skal vælge Capstar. Hvis din hund eller kat pludselig har været i kontakt med lopper – eksempelvis været på besøg i et loppeplaget hjem. Når din kat eller hund har fået en tablet, vil de lopper der er på dit kæledyr lige nu, blive dræbt inden for 15-30 min. Produktet virker dog kun i ca 24 timer og derfor kun det velegnet hvis katten eller hunden pludselig er kommet i kontakt med mange lopper.
Der findes rigtig mange andre produkter, end de 5 vi har nævnt herover
De der er nævnt, dækker behovet for langt de fleste. Har du spørgsmål om produkterne eller vil du gerne have rådgivning til lige netop dit behov, er du velkommen til at ringe eller komme forbi klinikken for en snak med os.
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Medicine for cats & kitten
Easotic ear suspension for dogs 10 ml
Treatment of acute otitis externa associated with bacteria (malassezia pachydermatis, gentamicin and fungi) in dogs
Boehringer Ingelheim
Semintra 4 mg/ml oral solution for cats 30 ml
Reduction of proteinuria associated with chronic kidney disease in cats
Broadline spot-on solution for cats between 2.5 and 7.5 kg 3 pipettes
For cats with, or at risk from mixed infestations by cestodes, nematodes and ectoparasites
Easotic ear suspension for dogs 10 ml
Treatment of acute otitis externa associated with bacteria (malassezia pachydermatis, gentamicin and fungi) in dogs
Boehringer Ingelheim
Semintra 4 mg/ml oral solution for cats 30 ml
Reduction of proteinuria associated with chronic kidney disease in cats
Broadline spot-on solution for cats between 2.5 and 7.5 kg 3 pipettes
For cats with, or at risk from mixed infestations by cestodes, nematodes and ectoparasites
Medicine for dogs & puppies
Bravecto 1000 mg for dogs between 20 and 40 kg 1 chewable tablet
Treatment of tick and flea infestations in dogs
Apoquel 5.4 mg for dogs 100 tablets
Treatment of pruritus (itching) associated with allergic dermatitis in dogs
Surolan 23 mg/ml ear drops and cutaneous suspension for cats and dogs 15 ml
Treatment of otitis externa and skin infections in cats and dogs
Bravecto 1000 mg for dogs between 20 and 40 kg 1 chewable tablet
Treatment of tick and flea infestations in dogs
Apoquel 5.4 mg for dogs 100 tablets
Treatment of pruritus (itching) associated with allergic dermatitis in dogs
Surolan 23 mg/ml ear drops and cutaneous suspension for cats and dogs 15 ml
Treatment of otitis externa and skin infections in cats and dogs
Medicine for horses
Imaverol 100 mg/ml concentrate for cutaneous emulsion for cattle, horses and dogs 100 ml
For the treatment of dermatomycoses in cattle, horses and dogs
Panacur 10% oral suspension for cattle, sheep, horses and other equines 1 l
A broad spectrum anthelmintic / wormer
Imaverol 100 mg/ml concentrate for cutaneous emulsion for cattle, horses and dogs 100 ml
For the treatment of dermatomycoses in cattle, horses and dogs
Panacur 10% oral suspension for cattle, sheep, horses and other equines 1 l
A broad spectrum anthelmintic / wormer
New products Medicine for cats & kitten
VetPlus > Coatex efa gel for cats and dogs 150 ml
VetPlus > Coatex efa gel for cats and dogs 65 ml
VetPlus > Coatex efa for cats and dogs 240 capsules
Vétoquinol > Derma for cats and dogs 90 capsules
New products Medicine for dogs & puppies
VetPlus > Coatex efa gel for cats and dogs 150 ml
VetPlus > Coatex efa gel for cats and dogs 65 ml
VetPlus > Coatex efa for cats and dogs 240 capsules
Vétoquinol > Clindaseptin 150 mg for dogs 1 capsule
New products Medicine for horses
Boehringer Ingelheim > Equisolon 33 mg/g oral powder for horses 180 g
Karizoo > Flunixin 50 mg/ml solution for injection for cattle, horses and pigs 100 ml
Virbac > Eraquell equimel ivermectin 18.7 mg/g for horses 48 syringes of 7.49 g
Esteve > Imaverol 100 mg/ml concentrate for cutaneous emulsion for cattle.
Medicine for cats & kitten
Surolan 23 mg/ml ear drops and cutaneous.
Treatment of otitis externa and skin infections in cats and dogs
Easotic ear suspension for dogs 10 ml
Treatment of acute otitis externa associated with bacteria (malassezia pachydermatis, gentamicin and fungi) in dogs
Boehringer Ingelheim
Semintra 4 mg/ml oral solution for cats 30 ml
Reduction of proteinuria associated with chronic kidney disease in cats
Medicine for dogs & puppies
Bravecto 1000 mg for dogs between 20 and.
Treatment of tick and flea infestations in dogs
Apoquel 5.4 mg for dogs 100 tablets
Treatment of pruritus (itching) associated with allergic dermatitis in dogs
Vétoquinol
Cimalgex cimicoxib 80 mg for dogs 32.
Treatment of pain and inflammation associated with osteoarthritis, and the management of perioperative pain due to orthopaedic or soft tissue surgery in dogs
Medicine for horses
For the treatment of dermatomycoses in cattle, horses and dogs
Panacur 10% oral suspension for cattle.
A broad spectrum anthelmintic / wormer
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Bravecto Medium Dog (10 - 20kg)
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Bravecto for Dogs: Bravecto Medium Dog 10 - 20kg
Save money on treating and preventing fleas and ticks with Bravecto for dogs.
These Bravecto Chew Tablets are for the treatment of tick and flea infestations in dogs. The tablets provide 12 weeks of flea and tick protection with just one treatment - 3 times longer that standard monthly treatments saving you money on keeping your dog free from parasites.
Bravecto for dogs 'Medium Dog' is supplied in single 500mg tablets.
Save over 50% on Bravecto for Dogs by shopping with Pet Drugs Online.
Bravecto for dogs is supplied in chewable tablets which most chew voluntarily, either on their own or with food.
Which Bravecto for dogs product do you need?
Bravecto for dogs is a prescription item and will be sent once a valid prescription is received.
A great cost-effective solution to fleas and ticks:
- Bravecto starts killing fleas within 2 hours and kills over 98% of fleas within just 12 hours.
- Bravecto kills 100% of ticks on dogs within 12 hours.
A safe option for pups and mothers
- Bravecto is safe for puppies aged 6 months or older.
- Bravecto Chew for dogs can be given to breeding, pregnant and lactating dogs.
How does Bravecto for Dogs work?
- After you give your dog Bravecto it travels tissue fluids just underneath your dog's skin. As the fleas and ticks feed they ingest Bravecto and die.
- Bravecto for dogs starts killing fleas within just 2 hours and ticks within 12 hours.
- Bravecto continues to work for 12 weeks, killing fleas, preventing infestations and also killing lone star ticks for 8 weeks.
To check the most up to date information about this product, please read its Summary of Product Characteristics (SPC) on the Veterinary Medical Directorate’s (VMD) Product Information Database:
For orders over £29 postage is free. For orders under £29 we charge £2.99 for postage
For Light items (under 2kg) our standard method is Royal Mail Second Class (there are a few exceptions, so if in doubt check our Delivery page).
For more information, view our Delivery page.
Product reviews for prescription products are not allowed by the RCVS. But here is what our customers say about our service:
Service reviews have been compiled from 36970 customer reviews
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Fantastic product, our dog has taken to " gastro intestnal low fat " very well and she likes it. Delivery was very fast and the price was better that the vet's
Quickly received, thank you
Prices are well below the vets prices and with trouble free ordering and delivery!
Easy to order, quick delivery. But would be better if you could register more than 1 pet. Great service many thanks Gary
great - no problems at all
As usual, great service. Good price and would recommend
Fast reliable service, easy to use and far cheaper than buying from vets
Easy to use site and a lot cheaper than the vets!
The service is great it’s easy to order on line I think this is the third time I’ve used this online service will be using it again and again great value for money cheaper than the vets 👍
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